| UniProt Protein Function: | CCR10: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17q21.1-q21.3 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function: G-protein coupled receptor activity |
| UniProt Protein Details: | |
| NCBI Summary: | Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | P46092 |
| NCBI GenInfo Identifier: | 62298314 |
| NCBI Gene ID: | 2826 |
| NCBI Accession: | P46092.3 |
| UniProt Secondary Accession: | P46092,Q4V749, Q6T7X2, Q9NZG2 |
| UniProt Related Accession: | P46092 |
| Molecular Weight: | 38,416 Da |
| NCBI Full Name: | C-C chemokine receptor type 10 |
| NCBI Synonym Full Names: | C-C motif chemokine receptor 10 |
| NCBI Official Symbol: | CCR10 |
| NCBI Official Synonym Symbols: | GPR2 |
| NCBI Protein Information: | C-C chemokine receptor type 10 |
| UniProt Protein Name: | C-C chemokine receptor type 10 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 2 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR10 |
| UniProt Entry Name: | CCR10_HUMAN |
