Anti-CCL19 Antibody (CAB16972)

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SKU:
CAB16972
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-CCL19 Antibody
Antibody SKU:CAB16972
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-95 of human CCL19 (NP_006265.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-95 of human CCL19 (NP_006265.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GTND AEDC CLSV TQKP IPGY IVRN FHYL LIKD GCRV PAVV FTTL RGRQ LCAP PDQP WVER IIQR LQRT SAKM KR
Gene ID:6363
Uniprot:Q99731
Cellular Location:
Calculated MW:10kDa
Observed MW:Refer to figures
Synonyms:CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19
Background:This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
UniProt Protein Function:CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function:CCR chemokine receptor binding; chemokine activity; chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding

Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; activation of JNK activity; positive regulation of receptor-mediated endocytosis; dendritic cell chemotaxis; cell communication; establishment of T cell polarity; positive regulation of T cell proliferation; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation

NCBI Summary:This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
UniProt Code:Q99731
NCBI GenInfo Identifier:2842763
NCBI Gene ID:6363
NCBI Accession:Q99731.1
UniProt Secondary Accession:Q99731,O00697, O00736,
UniProt Related Accession:Q99731
Molecular Weight:10,993 Da
NCBI Full Name:C-C motif chemokine 19
NCBI Synonym Full Names:chemokine (C-C motif) ligand 19
NCBI Official Symbol:CCL19  
NCBI Official Synonym Symbols:ELC; CKb11; MIP3B; MIP-3b; SCYA19  
NCBI Protein Information:C-C motif chemokine 19; exodus-3; CK beta-11; MIP-3-beta; EBI1 ligand chemokine; EBI1-ligand chemokine; CC chemokine ligand 19; beta chemokine exodus-3; beta-chemokine exodus-3; small-inducible cytokine A19; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; epstein-Barr virus-induced molecule 1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19
UniProt Protein Name:C-C motif chemokine 19
UniProt Synonym Protein Names:Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Macrophage inflammatory protein 3 beta; MIP-3-beta; Small-inducible cytokine A19
UniProt Gene Name:CCL19  
UniProt Entry Name:CCL19_HUMAN
Anti-CCL19 Antibody (CAB16972)Western blot analysis of extracts of rat lung, using CCL19 antibody (CAB16972) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CCL19 Antibody (CAB16972)Immunofluorescence analysis of rat spleen using CCL19 Polyclonal Antibody (CAB16972) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-CCL19 Antibody (CAB16972)Immunofluorescence analysis of human spleen using CCL19 Polyclonal Antibody (CAB16972) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-CCL19 Antibody (CAB16972)Immunofluorescence analysis of mouse spleen using CCL19 Polyclonal Antibody (CAB16972) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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