Anti-CBP80 Antibody (CAB13939)
- SKU:
- CAB13939
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-CBP80 Antibody |
| Antibody SKU: | CAB13939 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human CBP80 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NIH/3T3, Mouse testis, Mouse brain |
| Immunogen: | A synthetic peptide of human CBP80 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4686 |
| Uniprot: | Q09161 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 91kDa |
| Observed MW: | 100KDa |
| Synonyms: | NCBP1, CBP80, NCBP, Sto1 |
| Background: | The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. |
| UniProt Protein Function: | NCBP1: mediates U snRNA export from the nucleus. Binds to 5' capped mRNA. Found in aU snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX. Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2. |
| UniProt Protein Details: | Protein type:Translation; RNA processing; Spliceosome Chromosomal Location of Human Ortholog: 9q34.1 Cellular Component: cytoplasm; cytosol; mitochondrion; mRNA cap complex; nucleoplasm; nucleus; ribonucleoprotein complex Molecular Function:protein binding; RNA binding; RNA cap binding Biological Process: gene expression; histone mRNA metabolic process; mRNA 3'-end processing; mRNA capping; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of cell growth; positive regulation of mRNA 3'-end processing; positive regulation of viral transcription; regulation of translational initiation; RNA elongation from RNA polymerase II promoter; RNA splicing; RNA-mediated gene silencing; spliceosomal snRNP biogenesis; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; viral reproduction |
| NCBI Summary: | The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q09161 |
| NCBI GenInfo Identifier: | 1705654 |
| NCBI Gene ID: | 4686 |
| NCBI Accession: | Q09161.1 |
| UniProt Secondary Accession: | Q09161,Q59G76, Q5T1V0, Q5T7X2, B2R718, |
| UniProt Related Accession: | Q09161 |
| Molecular Weight: | 91,839 Da |
| NCBI Full Name: | Nuclear cap-binding protein subunit 1 |
| NCBI Synonym Full Names: | nuclear cap binding protein subunit 1 |
| NCBI Official Symbol: | NCBP1 |
| NCBI Official Synonym Symbols: | NCBP; Sto1; CBP80 |
| NCBI Protein Information: | nuclear cap-binding protein subunit 1 |
| UniProt Protein Name: | Nuclear cap-binding protein subunit 1 |
| UniProt Synonym Protein Names: | 80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit |
| Protein Family: | CBP80/20-dependent translation initiation factor |
| UniProt Gene Name: | NCBP1 |
| UniProt Entry Name: | NCBP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CBP80 antibody (CAB13939) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Western blot analysis of extracts of various cell lines, using CBP80 antibody (CAB13939) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human brain using CBP80 Rabbit pAb (CAB13939) at dilution of 1:100 (40x lens). |
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