Anti-CAST Antibody (CAB16789)
- SKU:
- CAB16789
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CAST Antibody |
| Antibody SKU: | CAB16789 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CAST (NP_001177371.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HeLa, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CAST (NP_001177371.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNPT ETKA IPVS QQME GPHL PNKK KHKK QAVK TEPE KKSQ STKL SVVH EKKS QEGK PKEH TEPK SLPK QASD TGSN DAHN KKAV SRSA EQQP SEKS TEPK TKPQ DMIS AGGE SVAG ITAI SGKP GDKK KEKK SLTP AVPV ESKP DKPS GKSG MDAA LDDL IDTL GGPE ETEE ENTT YTGP EVSD PMSS TYIE ELGK REVT IPPK YREL LAKP IGPD DAID ALSS DFTC GSPT AAGK KTEK EEST EVLK AQSA GTVR SAAP PQEK KRKV EKDT MSDQ ALEA LSAS LGTR QAEP ELDL RSIK EVDE AKAK EEKL EKCG EDDE TIPS EYRL KPAT DKDG KPLL PEPE EKPK PR |
| Gene ID: | 831 |
| Uniprot: | P20810 |
| Cellular Location: | |
| Calculated MW: | 63kDa/71- 84kDa |
| Observed MW: | 120kDa |
 | Western blot - CAST Polyclonal Antibody (CAB16789) |
| Synonyms: | CAST, BS-17, PLACK |
| Background: | The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | calpastatin: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 5q15 Cellular Component: membrane; cytoplasm; cytosol Molecular Function:protein binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity Disease: Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads |
| NCBI Summary: | The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P20810 |
| NCBI GenInfo Identifier: | 126302556 |
| NCBI Gene ID: | 831 |
| NCBI Accession: | P20810.4 |
| UniProt Related Accession: | P20810 |
| Molecular Weight: | 63kDa; 71-84kDa |
| NCBI Full Name: | Calpastatin |
| NCBI Synonym Full Names: | calpastatin |
| NCBI Official Symbol: | CAST |
| NCBI Official Synonym Symbols: | BS-17; PLACK |
| NCBI Protein Information: | calpastatin |
| UniProt Protein Name: | Calpastatin |
| UniProt Synonym Protein Names: | Calpain inhibitor; Sperm BS-17 component |
| Protein Family: | Calpastatin |
| UniProt Gene Name: | CAST |
| UniProt Entry Name: | ICAL_HUMAN |
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