Anti-CASR Antibody (CAB1426)
- SKU:
- CAB1426
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CASR Antibody |
| Antibody SKU: | CAB1426 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 874-1088 of human CASR (NP_001171536.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SH-SY5Y, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 874-1088 of human CASR (NP_001171536.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PSRN TIEE VRCS TAAH AFKV AARA TLRR SNVS RKRS SSLG GSTG STPS SSIS SKSN SEDP FPQP ERQK QQQP LALT QQEQ QQQP LTLP QQQR SQQQ PRCK QKVI FGSG TVTF SLSF DEPQ KNAM AHRN STHQ NSLE AQKS SDTL TRHQ PLLP LQCG ETDL DLTV QETG LQGP VGGD QRPE VEDP EELS PALV VSSS QSFV ISGG GSTV TENV VNS |
| Gene ID: | 846 |
| Uniprot: | P41180 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 120kDa/121kDa |
| Observed MW: | 150kDa |
| Synonyms: | CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasR |
| Background: | The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. |
| UniProt Protein Function: | CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis; GPCR, family 3 Chromosomal Location of Human Ortholog: 3q13 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:phosphoinositide phospholipase C activity; protein binding Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; ossification Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I |
| NCBI Summary: | The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41180 |
| NCBI GenInfo Identifier: | 1168781 |
| NCBI Gene ID: | 846 |
| NCBI Accession: | P41180.2 |
| UniProt Secondary Accession: | P41180,Q13912, Q16108, Q16109, Q16110, Q16379, Q2M1T0 Q4PJ19, |
| UniProt Related Accession: | P41180 |
| Molecular Weight: | 121,772 Da |
| NCBI Full Name: | Extracellular calcium-sensing receptor |
| NCBI Synonym Full Names: | calcium sensing receptor |
| NCBI Official Symbol: | CASR |
| NCBI Official Synonym Symbols: | CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1 |
| NCBI Protein Information: | extracellular calcium-sensing receptor |
| UniProt Protein Name: | Extracellular calcium-sensing receptor |
| UniProt Synonym Protein Names: | Parathyroid cell calcium-sensing receptor 1; PCaR1 |
| Protein Family: | Extracellular calcium-sensing receptor |
| UniProt Gene Name: | CASR |
| UniProt Entry Name: | CASR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CASR antibody (CAB1426) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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