Anti-Calpain small subunit 1 Antibody (CAB8859)
- SKU:
- CAB8859
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-Calpain small subunit 1 Antibody |
| Antibody SKU: | CAB8859 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Calpain small subunit 1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, A-549, Mouse brain, Rat lung |
| Immunogen: | A synthesized peptide derived from human Calpain small subunit 1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 826 |
| Uniprot: | P04632 |
| Cellular Location: | |
| Calculated MW: | 28kDa |
| Observed MW: | 28KDa |
| Synonyms: | CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1 |
| Background: | This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| UniProt Protein Function: | CAPNS1: Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. |
| UniProt Protein Details: | Protein type:Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: membrane; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of cell proliferation; proteolysis |
| NCBI Summary: | This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P04632 |
| NCBI GenInfo Identifier: | 115612 |
| NCBI Gene ID: | 826 |
| NCBI Accession: | P04632.1 |
| UniProt Related Accession: | P04632 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | Calpain small subunit 1 |
| NCBI Synonym Full Names: | calpain small subunit 1 |
| NCBI Official Symbol: | CAPNS1 |
| NCBI Official Synonym Symbols: | CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4 |
| NCBI Protein Information: | calpain small subunit 1 |
| UniProt Protein Name: | Calpain small subunit 1 |
| UniProt Synonym Protein Names: | Calcium-activated neutral proteinase small subunit; CANP small subunit; Calcium-dependent protease small subunit; CDPS; Calcium-dependent protease small subunit 1; Calpain regulatory subunit |
| Protein Family: | Calpain |
| UniProt Gene Name: | CAPNS1 |
| UniProt Entry Name: | CPNS1_HUMAN |
 | Western blot - Calpain small subunit 1 Rabbit mAb (CAB8859) |
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