Anti-CALCOCO2 Antibody (CAB7358)
- SKU:
- CAB7358
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| Antibody Name: | Anti-CALCOCO2 Antibody |
| Antibody SKU: | CAB7358 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-446 of human CALCOCO2 (NP_005822.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-446 of human CALCOCO2 (NP_005822.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TTQG EVEE IEQH NKEL CKEN QELK DSCI SLQK QNSD MQAE LQKK QEEL ETLQ SINK KLEL KVKE QKDY WETE LLQL KEQN QKMS SENE KMGI RVDQ LQAQ LSTQ EKEM EKLV QGDQ DKTE QLEQ LKKE NDHL FLSL TEQR KDQK KLEQ TVEQ MKQN ETTA MKKQ QELM DENF DLSK RLSE NEII CNAL QRQK ERLE GEND LLKR ENSR LLSY MGLD FNSL PYQV PTSD EGGA RQNP GLAY GNPY SGIQ ESSS PSPL SIKK CPIC KADD ICDH TLEQ QQMQ PLCF NCPI CDKI FPAT EKQI FEDH VFCH SL |
| Gene ID: | 10241 |
| Uniprot: | Q13137 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Peripheral membrane protein, autophagosome membrane, cytoskeleton, perinuclear region |
| Calculated MW: | 43kDa/47kDa/52kDa/54kDa/55kDa |
| Observed MW: | 52kDa |
| Synonyms: | CALCOCO2, NDP52 |
| Background: | This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | CALCOCO2: May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion. Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4. Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: Golgi apparatus; cytoskeleton; intracellular membrane-bound organelle; membrane; perinuclear region of cytoplasm; cytoplasm; nucleus Molecular Function:protein binding; protein homodimerization activity Biological Process: viral reproduction |
| NCBI Summary: | This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | Q13137 |
| NCBI GenInfo Identifier: | 74735623 |
| NCBI Gene ID: | 10241 |
| NCBI Accession: | Q13137.1 |
| UniProt Secondary Accession: | Q13137,Q53FQ5, Q53HB5, Q6IBN9, B2RBT0, B4DDC4, B4DDT4 B4DP36, B4E0C0, E7ENK0, E7ETP5, E9PBE5, |
| UniProt Related Accession: | Q13137 |
| Molecular Weight: | 446 |
| NCBI Full Name: | Calcium-binding and coiled-coil domain-containing protein 2 |
| NCBI Synonym Full Names: | calcium binding and coiled-coil domain 2 |
| NCBI Official Symbol: | CALCOCO2 |
| NCBI Official Synonym Symbols: | NDP52 |
| NCBI Protein Information: | calcium-binding and coiled-coil domain-containing protein 2; nuclear dot protein 52; nuclear domain 10 protein 52; nuclear domain 10 protein NDP52; antigen nuclear dot 52 kDa protein |
| UniProt Protein Name: | Calcium-binding and coiled-coil domain-containing protein 2 |
| UniProt Synonym Protein Names: | Antigen nuclear dot 52 kDa protein; Nuclear domain 10 protein NDP52; Nuclear domain 10 protein 52; Nuclear dot protein 52 |
| Protein Family: | Calcium-binding and coiled-coil domain-containing protein |
| UniProt Gene Name: | CALCOCO2 |
| UniProt Entry Name: | CACO2_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using CALCOCO2 antibody (CAB7358) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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