Anti-CADPS Antibody (CAB13186)
- SKU:
- CAB13186
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CADPS Antibody |
| Antibody SKU: | CAB13186 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1020-1100 of human CADPS (NP_899630.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1020-1100 of human CADPS (NP_899630.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASD MIES CVKR TRIA FEVK LQKT SRST DFRV PQSI CTMF NVMV DAKA QSTK LCSM EMGQ EHQY HSKI DELI EETV KEMI T |
| Gene ID: | 8618 |
| Uniprot: | Q9ULU8 |
| Cellular Location: | Cell junction, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, synapse |
| Calculated MW: | 50kDa/144kDa/148kDa/152kDa/153kDa |
| Observed MW: | 153kDa |
| Synonyms: | CADPS, CADPS1, CAPS, CAPS1, UNC-31 |
| Background: | This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. |
| UniProt Protein Function: | CADPS: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 3p14.2 Cellular Component: cytoplasmic vesicle membrane; synapse; cell junction; cytosol Molecular Function:protein binding; metal ion binding; lipid binding; protein kinase binding Biological Process: catecholamine secretion; protein transport; exocytosis; vesicle organization and biogenesis; synaptic vesicle priming |
| NCBI Summary: | This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q9ULU8 |
| NCBI GenInfo Identifier: | 34452715 |
| NCBI Gene ID: | 8618 |
| NCBI Accession: | NP_003707.2 |
| UniProt Secondary Accession: | Q9ULU8,Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2 A6NF60, |
| UniProt Related Accession: | Q9ULU8 |
| Molecular Weight: | 50,236 Da |
| NCBI Full Name: | calcium-dependent secretion activator 1 isoform 1 |
| NCBI Synonym Full Names: | Ca++-dependent secretion activator |
| NCBI Official Symbol: | CADPS |
| NCBI Official Synonym Symbols: | CAPS; CAPS1; CADPS1 |
| NCBI Protein Information: | calcium-dependent secretion activator 1; CAPS-1; Ca2+-dependent activator protein for secretion; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; calcium-dependent activator protein for secretion 1 |
| UniProt Protein Name: | Calcium-dependent secretion activator 1 |
| UniProt Synonym Protein Names: | Calcium-dependent activator protein for secretion 1; CAPS-1 |
| Protein Family: | Calcyphosin |
| UniProt Gene Name: | CADPS |
| UniProt Entry Name: | CAPS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CADPS antibody (CAB13186) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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