Anti-CADM2 Antibody (CAB11724)
- SKU:
- CAB11724
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CADM2 Antibody |
| Antibody SKU: | CAB11724 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-335 of human CADM2 (NP_001161147.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-335 of human CADM2 (NP_001161147.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NATP QVAM QVLE IHYT PSVK IIPS TPFP QEGQ PLIL TCES KGKP LPEP VLWT KDGG ELPD PDRM VVSG RELN ILFL NKTD NGTY RCEA TNTI GQSS AEYV LIVH DPNA LAGQ NGPD |
| Gene ID: | 253559 |
| Uniprot: | Q8N3J6 |
| Cellular Location: | Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, axon, synapse |
| Calculated MW: | 31kDa/35kDa/44kDa/47kDa |
| Observed MW: | 48kDa |
| Synonyms: | CADM2, IGSF4D, NECL3, Necl-3, SynCAM 2, synCAM2, SynCAM2 |
| Background: | This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CADM2: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3p12.1 Cellular Component: axon; cell-cell adherens junction; integral to plasma membrane; plasma membrane; synapse Molecular Function:cell adhesion molecule binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion; intercellular junction assembly and maintenance |
| NCBI Summary: | This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q8N3J6 |
| NCBI GenInfo Identifier: | 74759850 |
| NCBI Gene ID: | 253559 |
| NCBI Accession: | Q8N3J6.1 |
| UniProt Secondary Accession: | Q8N3J6,Q3KQY9, Q658Q7, Q8IZP8, G3XHN7, G3XHN8, |
| UniProt Related Accession: | Q8N3J6 |
| Molecular Weight: | 35,410 Da |
| NCBI Full Name: | Cell adhesion molecule 2 |
| NCBI Synonym Full Names: | cell adhesion molecule 2 |
| NCBI Official Symbol: | CADM2 |
| NCBI Official Synonym Symbols: | NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2 |
| NCBI Protein Information: | cell adhesion molecule 2 |
| UniProt Protein Name: | Cell adhesion molecule 2 |
| UniProt Synonym Protein Names: | Immunoglobulin superfamily member 4D; IgSF4D; Nectin-like protein 3; NECL-3; Synaptic cell adhesion molecule 2; SynCAM 2 |
| Protein Family: | Cell adhesion molecule |
| UniProt Gene Name: | CADM2 |
| UniProt Entry Name: | CADM2_HUMAN |
 | Western blot analysis of extracts of mouse liver, using CADM2 antibody (CAB11724) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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