Anti-CACNG2 Antibody (CAB6537)
- SKU:
- CAB6537
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CACNG2 Antibody |
| Antibody SKU: | CAB6537 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-323 of human CACNG2 (NP_006069.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-323 of human CACNG2 (NP_006069.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RHKQ LRAT ARAT DYLQ ASAI TRIP SYRY RYQR RSRS SSRS TEPS HSRD ASPV GIKG FNTL PSTE ISMY TLSR DPLK AATT PTAT YNSD RDNS FLQV HNCI QKEN KDSL HSNT ANRR TTPV |
| Gene ID: | 10369 |
| Uniprot: | Q9Y698 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 35kDa |
| Observed MW: | 36kDa |
| Synonyms: | CACNG2, MRD10 |
| Background: | The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. |
| UniProt Protein Function: | Stargazin: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: plasma membrane; voltage-gated calcium channel complex Molecular Function:channel regulator activity; ionotropic glutamate receptor binding; protein binding; voltage-gated calcium channel activity Biological Process: membrane depolarization; membrane hyperpolarization; neuromuscular junction development; synaptic transmission; transmission of nerve impulse; transport Disease: Mental Retardation, Autosomal Dominant 10 |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9Y698 |
| NCBI GenInfo Identifier: | 6685289 |
| NCBI Gene ID: | 10369 |
| NCBI Accession: | Q9Y698.1 |
| UniProt Secondary Accession: | Q9Y698,Q2M1M1, Q5TGT3, Q9UGZ7, |
| UniProt Related Accession: | Q9Y698 |
| Molecular Weight: | 35,966 Da |
| NCBI Full Name: | Voltage-dependent calcium channel gamma-2 subunit |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit gamma 2 |
| NCBI Official Symbol: | CACNG2 |
| NCBI Official Synonym Symbols: | MRD10 |
| NCBI Protein Information: | voltage-dependent calcium channel gamma-2 subunit |
| UniProt Protein Name: | Voltage-dependent calcium channel gamma-2 subunit |
| UniProt Synonym Protein Names: | Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2 |
| Protein Family: | Voltage-dependent calcium channel |
| UniProt Gene Name: | CACNG2 |
| UniProt Entry Name: | CCG2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CACNG2 Antibody (CAB6537) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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