Anti-CABLES1 Antibody (CAB10335)
- SKU:
- CAB10335
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-CABLES1 Antibody |
| Antibody SKU: | CAB10335 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CABLES1 (NP_612384.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, HT-29, A-549, HL-60, HeLa, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CABLES1 (NP_612384.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLSK RGCH ARIY ADFP IRRL ISQR SSLE TLED IEEN APLR RCRT LSGS PRPK NFKK IHFI KNMR QHDT RNGR IVLI SGRR SFCS IFSV LPYR DSTQ VGDL KLDG GRQS TGAV SLKE IIGL EGVE LGAD GKTV SYTQ FLLP TNAF GARR NTID STSS FSQF RNLS HRSL SIGR ASGT QGSL DTGS DLGD FMDY DPNL LDDP QWPC GKHK RVLI FPSY MTTV IDYV KPSD LKKD MNET FKEK FPHI KLTL SKIR SLKR EMRK LAQE DCGL EEPT VAMA FVYF EKLA LKGK LNKQ NRKL CAGA CVLL AAKI GSDL KKHE VKHL IDKL EEKF RLNR RELI AFEF PVLV ALEF ALHL PEHE VMPH YRRL VQSS |
| Gene ID: | 91768 |
| Uniprot: | Q8TDN4 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 15kDa/34kDa/41kDa/67kDa |
| Observed MW: | 67kDa |
| Synonyms: | CABLES1, CABL1, CABLES, HsT2563, IK3-1 |
| Background: | This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CABLES1: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death. Belongs to the cyclin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 18q11.2 Cellular Component: cytosol Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q8TDN4 |
| NCBI GenInfo Identifier: | 73921298 |
| NCBI Gene ID: | 91768 |
| NCBI Accession: | Q8TDN4.2 |
| UniProt Secondary Accession: | Q8TDN4,Q8N3Y8, Q8NA22, Q9BTG1, B4DK60, |
| UniProt Related Accession: | Q8TDN4 |
| Molecular Weight: | 68kDa |
| NCBI Full Name: | CDK5 and ABL1 enzyme substrate 1 |
| NCBI Synonym Full Names: | Cdk5 and Abl enzyme substrate 1 |
| NCBI Official Symbol: | CABLES1 |
| NCBI Official Synonym Symbols: | CABL1; IK3-1; CABLES; HsT2563 |
| NCBI Protein Information: | CDK5 and ABL1 enzyme substrate 1 |
| UniProt Protein Name: | CDK5 and ABL1 enzyme substrate 1 |
| UniProt Synonym Protein Names: | Interactor with CDK3 1; Ik3-1 |
| Protein Family: | CDK5 and ABL1 enzyme substrate |
| UniProt Gene Name: | CABLES1 |
 | Western blot analysis of extracts of various cell lines, using CABLES1 antibody (CAB10335) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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