Anti-C8orf4 Antibody (CAB6241)
- SKU:
- CAB6241
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-C8orf4 Antibody |
| Antibody SKU: | CAB6241 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKAK RSHQ AIIM STSL RVSP SIHG YHFD TASR KKAV GNIF ENTD QESL ERLF RNSG DKKA EERA KIIF AIDQ DVEE KTRA LMAL KKRT KDKL FQFL KLRK YSIK VH |
| Gene ID: | 56892 |
| Uniprot: | Q9NR00 |
| Cellular Location: | Cytoplasm, Nucleus, Nucleus speckle, nucleolus |
| Calculated MW: | 12kDa |
| Observed MW: | Refer to figures |
| Synonyms: | C8orf4, TC-1, TC1 |
| Background: | This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. |
| UniProt Protein Function: | C8orf4: May decrease apoptosis. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 8p11.2 Biological Process: apoptosis |
| NCBI Summary: | This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9NR00 |
| NCBI GenInfo Identifier: | 296434443 |
| NCBI Gene ID: | 56892 |
| NCBI Accession: | Q9NR00.2 |
| UniProt Related Accession: | Q9NR00 |
| Molecular Weight: | 106 |
| NCBI Full Name: | Uncharacterized protein C8orf4 |
| NCBI Synonym Full Names: | chromosome 8 open reading frame 4 |
| NCBI Official Symbol: | C8orf4 |
| NCBI Official Synonym Symbols: | TC1; TC-1 |
| NCBI Protein Information: | uncharacterized protein C8orf4; human thyroid cancer 1; thyroid cancer protein 1 |
| UniProt Protein Name: | Uncharacterized protein C8orf4 |
| UniProt Synonym Protein Names: | Thyroid cancer protein 1; TC-1 |
| Protein Family: | Protein |
| UniProt Gene Name: | C8orf4 |
| UniProt Entry Name: | CH004_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens). |
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