Anti-BRSK1 Antibody (CAB17226)

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SKU:
CAB17226
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-BRSK1 Antibody
Antibody SKU:CAB17226
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 310-510 of human BRSK1 (NP_115806.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 310-510 of human BRSK1 (NP_115806.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PSNG ELDP DVLE SMAS LGCF RDRE RLHR ELRS EEEN QEKM IYYL LLDR KERY PSCE DQDL PPRN DVDP PRKR VDSP MLSR HGKR RPER KSME VLSI TDAG GGGS PVPT RRAL EMAQ HSQR SRSV SGAS TGLS SSPL SSPR SPVF SFSP EPGA GDEA RGGG SPTS KTQT LPSR GPRG GGAG EQPP PPSA RSTP LPGP PGSP R
Gene ID:84446
Uniprot:Q8TDC3
Cellular Location:Cell junction, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, synapse
Calculated MW:38kDa/85kDa/86kDa
Observed MW:90KDa
Anti-BRSK1 Antibody (CAB17226)Western blot - BRSK1 Rabbit pAb (CAB17226)
Synonyms:BRSK1, hSAD1
Background:
UniProt Protein Function:BRSK1: a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. Acts as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Translocates from the cytoplasm to the nucleus in response to UV- or MMS-induced DNA damage. BRSK1 and BRSK2 are required for neuronal polarization. Widely expressed with highest levels in the brain and testis. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.26; EC 2.7.11.1; CAMK group; CAMKL family; BRSK subfamily

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: nucleoplasm; centrosome; synaptic vesicle; cytoplasm; cell junction; nucleus

Molecular Function:protein serine/threonine kinase activity; gamma-tubulin binding; tau-protein kinase activity; magnesium ion binding; protein kinase binding; ATP binding

Biological Process: neuron differentiation; axonogenesis; establishment of cell polarity; neurotransmitter secretion; response to ionizing radiation; G2/M transition DNA damage checkpoint; centrosome duplication; response to DNA damage stimulus; protein amino acid phosphorylation; response to UV

UniProt Code:Q8TDC3
NCBI GenInfo Identifier:34395684
NCBI Gene ID:84446
NCBI Accession:Q8TDC3.1
UniProt Secondary Accession:Q8TDC3,Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4 F1DG44,
UniProt Related Accession:Q8TDC3
Molecular Weight:38,782 Da
NCBI Full Name:BR serine/threonine-protein kinase 1
NCBI Synonym Full Names:BR serine/threonine kinase 1
NCBI Official Symbol:BRSK1  
NCBI Official Synonym Symbols:hSAD1  
NCBI Protein Information:serine/threonine-protein kinase BRSK1; SAD1 kinase; SAD1 homolog; protein kinase SAD1A; brain-selective kinase 1; SadB kinase short isoform; BR serine/threonine-protein kinase 1; serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1; brain-specific serine/threonine-protein kinase 1
UniProt Protein Name:Serine/threonine-protein kinase BRSK1
UniProt Synonym Protein Names:Brain-selective kinase 1 (EC:2.7.11.26); Brain-specific serine/threonine-protein kinase 1; BR serine/threonine-protein kinase 1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1; SAD1 homolog; hSAD1
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:BRSK1  
UniProt Entry Name:BRSK1_HUMAN

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