Anti-BORA Antibody (CAB13847)
- SKU:
- CAB13847
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-BORA Antibody |
| Antibody SKU: | CAB13847 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-619 of human BORA (NP_079084.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-619 of human BORA (NP_079084.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KYSL GSIT SPSP ISSP TFSP IEFQ IGET PLSE QRKF TVHS PDAS SGTN SNGI TNPC IRSP YIDG CSPI KNWS PMRL QMYS GGTQ YRTS VIQI PFTL ETQG EDEE DKEN IPST DVSS PAMD AAGI HLRQ FSNE ASTH GTHL VVTA MSVT QNQS SASE KELA LLQD VERE KDNN TVDM VDPI EIAD ETTW IKEP VDNG SLPM TDFV SGIA FSIE NSHM CMSP LAES SVIP CESS NIQM DSGY NTQN CGSN IMDT VGAE SYCK ESDA QTCE VESK SQAF NMKQ DHTT QRCW MKTA SPFQ CSSP |
| Gene ID: | 79866 |
| Uniprot: | Q6PGQ7 |
| Cellular Location: | |
| Calculated MW: | 53kDa/61kDa |
| Observed MW: | 90kDa |
| Synonyms: | BORA, C13orf34 |
| Background: |
| UniProt Protein Function: | BORA: Required for the activation of AURKA at the onset of mitosis. Interacts with AURKA. Belongs to the BORA family. |
| UniProt Protein Details: | Protein type:Activator Chromosomal Location of Human Ortholog: 13q22.1 Cellular Component: cytosol Molecular Function:protein binding; protein kinase binding Biological Process: mitosis; regulation of protein localization; cell division; regulation of mitosis; mitotic cell cycle; G2/M transition of mitotic cell cycle |
| NCBI Summary: | BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6PGQ7 |
| NCBI GenInfo Identifier: | 74737659 |
| NCBI Gene ID: | 79866 |
| NCBI Accession: | Q6PGQ7.2 |
| UniProt Related Accession: | Q6PGQ7 |
| Molecular Weight: | 61 kDa |
| NCBI Full Name: | Protein aurora borealis |
| NCBI Synonym Full Names: | BORA aurora kinase A activator |
| NCBI Official Symbol: | BORA |
| NCBI Official Synonym Symbols: | C13orf34 |
| NCBI Protein Information: | protein aurora borealis |
| UniProt Protein Name: | Protein aurora borealis |
| Protein Family: | Protein aurora borealis |
| UniProt Gene Name: | BORA |
| UniProt Entry Name: | BORA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BORA antibody (CAB13847) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s. |
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