Anti-BMX Antibody (CAB6358)
- SKU:
- CAB6358
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-BMX Antibody |
| Antibody SKU: | CAB6358 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human BMX (NP_001712.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | DU145, A375, Jurkat, HeLa, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human BMX (NP_001712.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDTK SILE ELLL KRSQ QKKK MSPN NYKE RLFV LTKT NLSY YEYD KMKR GSRK GSIE IKKI RCVE KVNL EEQT PVER QYPF QIVY KDGL LYVY ASNE ESRS QWLK ALQK EIRG NPHL LVKY |
| Gene ID: | 660 |
| Uniprot: | P51813 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 78kDa |
| Observed MW: | 78kDa |
| Synonyms: | BMX, ETK, PSCTK2, PSCTK3 |
| Background: | This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3, 4, 5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | Etk: a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Tec family Chromosomal Location of Human Ortholog: Xp22.2 Cellular Component: cytosol; extrinsic to internal side of plasma membrane Molecular Function:ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity Biological Process: apoptosis; cell structure disassembly during apoptosis; innate immune response; mesoderm development; NK T cell differentiation; programmed cell death; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P51813 |
| NCBI GenInfo Identifier: | 1705489 |
| NCBI Gene ID: | 660 |
| NCBI Accession: | P51813.1 |
| UniProt Secondary Accession: | P51813,O60564, Q12871, A6NIH9, |
| UniProt Related Accession: | P51813 |
| Molecular Weight: | |
| NCBI Full Name: | Cytoplasmic tyrosine-protein kinase BMX |
| NCBI Synonym Full Names: | BMX non-receptor tyrosine kinase |
| NCBI Official Symbol: | BMX |
| NCBI Official Synonym Symbols: | ETK; PSCTK2; PSCTK3 |
| NCBI Protein Information: | cytoplasmic tyrosine-protein kinase BMX |
| UniProt Protein Name: | Cytoplasmic tyrosine-protein kinase BMX |
| UniProt Synonym Protein Names: | Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38 |
| Protein Family: | Cytoplasmic tyrosine-protein kinase |
| UniProt Gene Name: | BMX |
| UniProt Entry Name: | BMX_HUMAN |