Anti-BMP6 Antibody (CAB15648)
- SKU:
- CAB15648
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-BMP6 Antibody |
| Antibody SKU: | CAB15648 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 375-513 of human BMP6 (NP_001709.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 375-513 of human BMP6 (NP_001709.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SASS RRRQ QSRN RSTQ SQDV ARVS SASD YNSS ELKT ACRK HELY VSFQ DLGW QDWI IAPK GYAA NYCD GECS FPLN AHMN ATNH AIVQ TLVH LMNP EYVP KPCC APTK LNAI SVLY FDDN SNVI LKKY RNMV VRAC GCH |
| Gene ID: | 654 |
| Uniprot: | P22004 |
| Cellular Location: | Secreted |
| Calculated MW: | 57kDa |
| Observed MW: |
| Synonyms: | BMP6, VGR, VGR1 |
| Background: | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. |
| UniProt Protein Function: | Induces cartilage and bone formation. |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P22004 |
| NCBI GenInfo Identifier: | 115076 |
| NCBI Gene ID: | 654 |
| NCBI Accession: | P22004.1 |
| UniProt Secondary Accession: | P22004,Q5TCP3, |
| UniProt Related Accession: | P22004 |
| Molecular Weight: | 57,226 Da |
| NCBI Full Name: | Bone morphogenetic protein 6 |
| NCBI Synonym Full Names: | bone morphogenetic protein 6 |
| NCBI Official Symbol: | BMP6 |
| NCBI Official Synonym Symbols: | VGR; VGR1 |
| NCBI Protein Information: | bone morphogenetic protein 6 |
| UniProt Protein Name: | Bone morphogenetic protein 6 |
| UniProt Synonym Protein Names: | VG-1-related protein; VG-1-R; VGR-1 |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP6 |
 | Immunofluorescence analysis of U2OS cells using BMP6 antibody (CAB15648) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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