Anti-BMP4 Antibody (CAB1565)

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SKU:
CAB1565
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-BMP4 Antibody
Antibody SKU:CAB1565
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human BMP4 (NP_570912.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human BMP4 (NP_570912.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TGKK KVAE IQGH AGGR RSGQ SHEL LRDF EATL LQMF GLRR RPQP SKSA VIPD YMRD LYRL QSGE EEEE QIHS TGLE YPER PASR ANTV RSFH HEEH LENI PGTS ENSA FRFL FNLS SIPE NEVI SSAE LRLF REQV DQGP DWER GFHR INIY EVMK PPAE VVPG HLIT RLLD TRLV HHNV TRWE TFDV SPAV LRWT REKQ PNYG LAIE VTHL HQTR THQG QHVR ISRS LPQG SGNW AQLR PLLV TFGH DGRG HALT RRRR AKRS PKHH SQR
Gene ID:652
Uniprot:P12644
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:46kDa
Observed MW:46kDa
Synonyms:BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
Background:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
UniProt Protein Function:BMP4: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q22.2

Cellular Component: extracellular region; extracellular space

Molecular Function:chemoattractant activity; cytokine activity; protein binding; transforming growth factor beta receptor binding

Biological Process: activation of MAPKK activity; alveolus development; blood vessel endothelial cell proliferation during sprouting angiogenesis; BMP signaling pathway; branching morphogenesis of a tube; chondrocyte differentiation; common-partner SMAD protein phosphorylation; endochondral ossification; hemopoietic progenitor cell differentiation; intermediate mesodermal cell differentiation; kidney development; lymphoid progenitor cell differentiation; macrophage differentiation; mesonephros development; monocyte differentiation; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of immature T cell proliferation in the thymus; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of myoblast differentiation; negative regulation of phosphorylation; negative regulation of striated muscle development; negative regulation of T cell differentiation in the thymus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis; osteoblast differentiation; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of cardiac muscle fiber development; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of epidermal cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; post-embryonic development; regulation of cell fate commitment; regulation of protein import into nucleus; smooth muscle development; smoothened signaling pathway; steroid hormone mediated signaling; telencephalon development; ureteric bud branching; ureteric bud development

Disease: Microphthalmia, Syndromic 6; Orofacial Cleft 11

NCBI Summary:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
UniProt Code:P12644
NCBI GenInfo Identifier:115073
NCBI Gene ID:652
NCBI Accession:P12644.1
UniProt Secondary Accession:P12644,Q9UM80,
UniProt Related Accession:P12644
Molecular Weight:47kDa
NCBI Full Name:Bone morphogenetic protein 4
NCBI Synonym Full Names:bone morphogenetic protein 4
NCBI Official Symbol:BMP4  
NCBI Official Synonym Symbols:ZYME; BMP2B; OFC11; BMP2B1; MCOPS6  
NCBI Protein Information:bone morphogenetic protein 4
UniProt Protein Name:Bone morphogenetic protein 4
UniProt Synonym Protein Names:Bone morphogenetic protein 2B; BMP-2B
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP4  
Anti-BMP4 Antibody (CAB1565)Western blot analysis of extracts of various cell lines, using BMP4 antibody (CAB1565) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

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