Anti-BMP2 Antibody (CAB0231)

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SKU:
CAB0231
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-BMP2 Antibody
Antibody SKU:CAB0231
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 283-396 of human BMP2 (NP_001191.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, THP-1, PC-12
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 283-396 of human BMP2 (NP_001191.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QAKH KQRK RLKS SCKR HPLY VDFS DVGW NDWI VAPP GYHA FYCH GECP FPLA DHLN STNH AIVQ TLVN SVNS KIPK ACCV PTEL SAIS MLYL DENE KVVL KNYQ DMVV EGCG CR
Gene ID:650
Uniprot:P12643
Cellular Location:Secreted
Calculated MW:44kDa
Observed MW:45kDa
Synonyms:BDA2, BMP2A, BMP2
Background:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
UniProt Protein Function:Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
NCBI Summary:The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
UniProt Code:P12643
NCBI GenInfo Identifier:115068
NCBI Gene ID:650
NCBI Accession:P12643.1
UniProt Related Accession:P12643
Molecular Weight:
NCBI Full Name:Bone morphogenetic protein 2
NCBI Synonym Full Names:bone morphogenetic protein 2
NCBI Official Symbol:BMP2  
NCBI Official Synonym Symbols:BDA2; BMP2A  
NCBI Protein Information:bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A
UniProt Protein Name:Bone morphogenetic protein 2
UniProt Synonym Protein Names:Bone morphogenetic protein 2A; BMP-2A
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP2  
UniProt Entry Name:BMP2_HUMAN
Anti-BMP2 Antibody (CAB0231)Western blot analysis of extracts of various cell lines, using BMP2 Antibody (CAB0231) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-BMP2 Antibody (CAB0231)Immunohistochemistry of paraffin-embedded human colon using BMP2 antibody (CAB0231) at dilution of 1:200 (40x lens).
Anti-BMP2 Antibody (CAB0231)Immunohistochemistry of paraffin-embedded mouse lung using BMP2 antibody (CAB0231) at dilution of 1:200 (40x lens).

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