Anti-BIN3 Antibody (CAB15478)
- SKU:
- CAB15478
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-BIN3 Antibody |
| Antibody SKU: | CAB15478 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human BIN3 (NP_061158.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, A431, HeLa, Mouse kidney, Mouse spleen, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human BIN3 (NP_061158.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSWI PFKI GQPK KQIV PKTV ERDF EREY GKLQ QLEE QTRR LQKD MKKS TDAD LAMS KSAV KISL DLLS NPLC EQDQ DLLN MVTA LDTA MKRM DAFN QEKV NQIQ KTVI EPLK KFGS VFPS LNMA VKRR EQAL QDYR RLQA KVEK YEEK EKTG PVLA KLHQ AREE LRPV REDF EAKN RQLL EEMP RFYG SRLD YFQP SFES LIRA QVVY YSEM HKIF GDLS HQLD QPGH SDEQ RERE NEAK LSEL RALS IVAD D |
| Gene ID: | 55909 |
| Uniprot: | Q9NQY0 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 23kDa/29kDa |
| Observed MW: | 35kDa |
| Synonyms: | BIN3 |
| Background: | The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. |
| UniProt Protein Function: | BIN3: Involved in cytokinesis and septation where it has a role in the localization of F-actin. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 8p21.3 Molecular Function:protein binding Biological Process: protein localization; unidimensional cell growth |
| NCBI Summary: | The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NQY0 |
| NCBI GenInfo Identifier: | 30912742 |
| NCBI Gene ID: | 55909 |
| NCBI Accession: | Q9NQY0.1 |
| UniProt Secondary Accession: | Q9NQY0,Q9BVG2, Q9NVY9, |
| UniProt Related Accession: | Q9NQY0 |
| Molecular Weight: | 23,218 Da |
| NCBI Full Name: | Bridging integrator 3 |
| NCBI Synonym Full Names: | bridging integrator 3 |
| NCBI Official Symbol: | BIN3 |
| NCBI Protein Information: | bridging integrator 3 |
| UniProt Protein Name: | Bridging integrator 3 |
| Protein Family: | Bridging integrator |
| UniProt Gene Name: | BIN3 |
| UniProt Entry Name: | BIN3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BIN3 antibody (CAB15478) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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