Anti-Bif-1 Antibody (CAB7104)
- SKU:
- CAB7104
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-Bif-1 Antibody |
| Antibody SKU: | CAB7104 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human Bif-1 (NP_057093.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human Bif-1 (NP_057093.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNIM DFNV KKLA ADAG TFLS RAVQ FTEE KLGQ AEKT ELDA HLEN LLSK AECT KIWT EKIM KQTE VLLQ PNPN ARIE EFVY EKLD RKAP SRIN NPEL LGQY MIDA GTEF GPGT AYGN ALIK CGET QKRI GTAD RELI QTSA LNFL TPLR NFIE GDYK TIAK ERKL LQNK RLDL DAAK TRLK KAKA AETR NSSE QELR ITQS EFDR QAEI TRLL LEGI SSTH AHHL RCLN DFVE AQMT YYAQ CYQY MLDL QKQL GSFP SNYL SNNN QTSV TPVP SVLP NAIG SSAM ASTS GLVI TSPS NLSD LKEC SGSR KARV LYDY DAAN STEL SLLA DEVI TVFS VVGM DSDW LMGE RGNQ KGKV PITY LELL N |
| Gene ID: | 51100 |
| Uniprot: | Q9Y371 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Golgi apparatus membrane, Midbody, Mitochondrion outer membrane, Peripheral membrane protein, autophagosome membrane |
| Calculated MW: | 29kDa/40kDa/43kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SH3GLB1, Bif-1, CGI-61, PPP1R70, dJ612B15.2 |
| Background: | This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | SH3GLB1: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis; EC 2.3.1.-; Autophagy; Transferase Chromosomal Location of Human Ortholog: 1p22 Cellular Component: cytoplasm; midbody Molecular Function:identical protein binding; protein binding; protein homodimerization activity Biological Process: autophagic cell death; cellular response to amino acid starvation; cellular response to glucose starvation; positive regulation of autophagy; positive regulation of protein oligomerization; protein oligomerization; receptor catabolic process; regulation of cytokinesis; regulation of macroautophagy; regulation of protein stability |
| NCBI Summary: | This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9Y371 |
| NCBI GenInfo Identifier: | 41018158 |
| NCBI Gene ID: | 51100 |
| NCBI Accession: | Q9Y371.1 |
| UniProt Secondary Accession: | Q9Y371,Q5H8U5, Q9H3Z0, Q9NR47, Q9NYA9, B4E182, |
| UniProt Related Accession: | Q9Y371 |
| Molecular Weight: | 29,318 Da |
| NCBI Full Name: | Endophilin-B1 |
| NCBI Synonym Full Names: | SH3 domain containing GRB2 like endophilin B1 |
| NCBI Official Symbol: | SH3GLB1 |
| NCBI Official Synonym Symbols: | Bif-1; CGI-61; PPP1R70; dJ612B15.2 |
| NCBI Protein Information: | endophilin-B1 |
| UniProt Protein Name: | Endophilin-B1 |
| UniProt Synonym Protein Names: | Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1 |
| Protein Family: | Endophilin |
| UniProt Gene Name: | SH3GLB1 |
| UniProt Entry Name: | SHLB1_HUMAN |
 | Immunofluorescence analysis of A549 cells using Bif-1 antibody (CAB7104). Blue: DAPI for nuclear staining. |
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