Anti-BDH1 Antibody (CAB3763)
- SKU:
- CAB3763
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-BDH1 Antibody |
| Antibody SKU: | CAB3763 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-343 of human BDH1 (NP_004042.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549, MCF7, SKOV3, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-343 of human BDH1 (NP_004042.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLAT RLSR PLSR LPGK TLSA CDRE NGAR RPLL LGST SFIP IGRR TYAS AAEP VGSK AVLV TGCD SGFG FSLA KHLH SKGF LVFA GCLM KDKG HDGV KELD SLNS DRLR TVQL NVCS SEEV EKVV EIVR SSLK DPEK GMWG LVNN AGIS TFGE VEFT SLET YKQV AEVN LWGT VRMT KSFL PLIR RAKG RVVN ISSM LGRM ANPA RSPY CITK FGVE AFSD CLRY EMYP LGVK VSVV EPGN FIAA TSLY SPES IQAI AKKM WEEL PEVV RKDY GKKY FDEK IAKM ETYC SSGS TDTS PVID AVTH ALTA TTPY TRYH PMDY YWWL RMQI MTHL PGAI SDMI YIR |
| Gene ID: | 622 |
| Uniprot: | Q02338 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 38kDa |
| Observed MW: | 42kDa |
| Synonyms: | BDH1, BDH, SDR9C1 |
| Background: | This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. |
| UniProt Protein Function: | BDH: a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - butanoate; Oxidoreductase; EC 1.1.1.30; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial Chromosomal Location of Human Ortholog: 3q29 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm; mitochondrial inner membrane Molecular Function:3-hydroxybutyrate dehydrogenase activity; phospholipid binding Biological Process: response to drug; response to toxin; cellular lipid metabolic process; ketone body metabolic process; liver development; response to estradiol stimulus; response to insulin stimulus; response to starvation; response to cadmium ion; response to ethanol; ketone body catabolic process; ketone body biosynthetic process; brain development; response to nutrient; response to corticosterone stimulus |
| NCBI Summary: | This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02338 |
| NCBI GenInfo Identifier: | 25108876 |
| NCBI Gene ID: | 622 |
| NCBI Accession: | Q02338.3 |
| UniProt Secondary Accession: | Q02338,Q96ET1, Q9BRZ4, D3DXC0, |
| UniProt Related Accession: | Q02338 |
| Molecular Weight: | 343 |
| NCBI Full Name: | D-beta-hydroxybutyrate dehydrogenase, mitochondrial |
| NCBI Synonym Full Names: | 3-hydroxybutyrate dehydrogenase, type 1 |
| NCBI Official Symbol: | BDH1 |
| NCBI Official Synonym Symbols: | BDH; SDR9C1 |
| NCBI Protein Information: | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; (R)-3-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase (heart, mitochondrial); short chain dehydrogenase/reductase family 9C, member 1 |
| UniProt Protein Name: | D-beta-hydroxybutyrate dehydrogenase, mitochondrial |
| UniProt Synonym Protein Names: | 3-hydroxybutyrate dehydrogenase |
| Protein Family: | (R,R)-butanediol dehydrogenase |
| UniProt Gene Name: | BDH1 |
| UniProt Entry Name: | BDH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BDH1 antibody (CAB3763) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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