| Synonyms: | BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas |
| Background: | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. |
| UniProt Protein Function: | P130Cas: a docking protein containing multiple protein-protein interaction domains. Plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. The amino-terminal SH3 domain regulates its interaction with focal adhesion kinase (FAK) and the FAK-related kinase PYK2 and also with tyrosine phosphatases PTP-1B and PTP-PEST. Overexpression confers antiestrogen resistance on breast cancer cells. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q23.1 Cellular Component: ruffle; focal adhesion; lamellipodium; cytoplasm; nucleolus; plasma membrane; cytosol; actin cytoskeleton Molecular Function:signal transducer activity; protein binding; SH3 domain binding; protein kinase binding Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; antigen receptor-mediated signaling pathway; platelet activation; cell migration; nerve growth factor receptor signaling pathway; actin filament organization; hepatocyte growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; T cell receptor signaling pathway; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; cell proliferation; B cell receptor signaling pathway; cell division; insulin receptor signaling pathway; regulation of cell growth; cell adhesion; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of cell migration |
| NCBI Summary: | BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009] |
| UniProt Code: | P56945 |
| NCBI GenInfo Identifier: | 288558806 |
| NCBI Gene ID: | 9564 |
| NCBI Accession: | P56945.2 |
| UniProt Secondary Accession: | P56945,B3KWD7, B4DEV4, B4DGB5, B4DIW5, B7Z7X7, E9PCL5 E9PCV2, F5GXA2, F5GXV6, F5H7Z0, F8WA69, |
| UniProt Related Accession: | P56945 |
| Molecular Weight: | 870 |
| NCBI Full Name: | Breast cancer anti-estrogen resistance protein 1 |
| NCBI Synonym Full Names: | breast cancer anti-estrogen resistance 1 |
| NCBI Official Symbol: | BCAR1 |
| NCBI Official Synonym Symbols: | CAS; CAS1; CASS1; CRKAS; P130Cas |
| NCBI Protein Information: | breast cancer anti-estrogen resistance protein 1; Crk-associated substrate p130Cas; Cas scaffolding protein family member 1 |
| UniProt Protein Name: | Breast cancer anti-estrogen resistance protein 1 |
| UniProt Synonym Protein Names: | CRK-associated substrate; Cas scaffolding protein family member 1; p130cas |
| Protein Family: | Breast cancer anti-estrogen resistance protein |
| UniProt Gene Name: | BCAR1 |
| UniProt Entry Name: | BCAR1_HUMAN |
