Anti-BAP31 Antibody (CAB2259)

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SKU:
CAB2259
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
6C6-AG
BAP31
CDM
DDCH
DXS1357E
Frequently bought together:

Description

Product Name:BAP31 Rabbit mAb
Product Code:CAB2259
Size:20uL, 50uL, 100uL
Synonyms:6C6-AG, BAP31, CDM, DDCH, DXS1357E
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human BAP31
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, U-251MG, Mouse lung, Mouse liver, Mouse kidney, Rat lung
Immunogen:A synthesized peptide derived from human BAP31
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10134
Uniprot:P51572
Cellular Location:Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Multi-pass membrane protein
Calculated MW:25kDa
Observed MW:28kDa
UniProt Protein Function:BCAP31 iso2: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; membrane; clathrin-coated vesicle; endoplasmic reticulum; integral to plasma membrane; lipid particle; cytosol

Molecular Function:protein binding; MHC class I protein binding; protein complex binding

Biological Process: intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; elevation of cytosolic calcium ion concentration; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of caspase activity; spermatogenesis; cell structure disassembly during apoptosis; elevation of mitochondrial calcium ion concentration

Disease: Deafness, Dystonia, And Cerebral Hypomyelination

NCBI Summary:This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]
UniProt Code:P51572
NCBI GenInfo Identifier:1705725
NCBI Gene ID:10134
NCBI Accession:P51572.3
UniProt Secondary Accession:P51572,Q13836, Q96CF0, B3KQ79, D3DWV5,
UniProt Related Accession:P51572
Molecular Weight:34,752 Da
NCBI Full Name:B-cell receptor-associated protein 31
NCBI Synonym Full Names:B-cell receptor-associated protein 31
NCBI Official Symbol:BCAP31  
NCBI Official Synonym Symbols:CDM; DDCH; BAP31; 6C6-AG; DXS1357E  
NCBI Protein Information:B-cell receptor-associated protein 31; p28 Bap31; BCR-associated protein Bap31; 6C6-AG tumor-associated antigen
UniProt Protein Name:B-cell receptor-associated protein 31
UniProt Synonym Protein Names:6C6-AG tumor-associated antigen; Protein CDM; p28
Protein Family:B-cell receptor-associated protein
UniProt Gene Name:BCAP31  
UniProt Entry Name:BAP31_HUMAN

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