Anti-BANP Antibody (CAB7595)
- SKU:
- CAB7595
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-BANP Antibody |
| Antibody SKU: | CAB7595 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human BANP (NP_060339.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human BANP (NP_060339.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMSE HDLA DVVQ IAVE DLSP DHPV VLEN HVVT DEDE PALK RQRL EINC QDPS IKSF LYSI NQTI CLRL DSIE AKLQ ALEA TCKS LEEK LDLV TNKQ HSPI QVPM VAGS PLGA TQTC NKVR CAVP GRRQ NTIV VKVP GQED SHHE DGES GSEA SDSV SSCG QAGS QSIG SNVT LITL NSEE DYPN GTWL GDEN NPEM RVRC AIIP SDML HIST NCRT AEKM ALTL LDYL FHRE VQAV SNLS GQGK HGKK QLDP LTIY GIRC |
| Gene ID: | 54971 |
| Uniprot: | Q8N9N5 |
| Cellular Location: | Nucleus |
| Calculated MW: | 48kDa/50kDa/51kDa/53kDa/54kDa/55kDa/56kDa |
| Observed MW: | 50kDa |
| Synonyms: | BANP, BEND1, SMAR1, SMARBP1 |
| Background: | This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | BANP: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest. Belongs to the BANP/SMAR1 family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 16q24 Cellular Component: nucleoplasm Molecular Function:protein binding; DNA binding; p53 binding Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; chromatin modification; negative regulation of protein catabolic process; cell cycle |
| NCBI Summary: | This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q8N9N5 |
| NCBI GenInfo Identifier: | 308153628 |
| NCBI Gene ID: | 54971 |
| NCBI Accession: | Q8N9N5.3 |
| UniProt Related Accession: | Q8N9N5 |
| Molecular Weight: | |
| NCBI Full Name: | Protein BANP |
| NCBI Synonym Full Names: | BTG3 associated nuclear protein |
| NCBI Official Symbol: | BANP |
| NCBI Official Synonym Symbols: | BEND1; SMAR1; SMARBP1 |
| NCBI Protein Information: | protein BANP |
| UniProt Protein Name: | Protein BANP |
| UniProt Synonym Protein Names: | BEN domain-containing protein 1; Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding protein |
| Protein Family: | Protein |
| UniProt Gene Name: | BANP |
| UniProt Entry Name: | BANP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BANP antibody (CAB7595) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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