Anti-B4GALT2 Antibody (CAB17573)
- SKU:
- CAB17573
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-B4GALT2 Antibody |
| Antibody SKU: | CAB17573 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 155-271 of human B4GALT2 (NP_085076.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, PC-3, OVCAR3, HT-29, Mouse brain, Mouse skeletal muscle, Mouse large intestine, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 155-271 of human B4GALT2 (NP_085076.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PGVL MGGR YTPP DCTP AQTV AVII PFRH REHH LRYW LHYL HPIL RRQR LRYG VYVI NQHG EDTF NRAK LLNV GFLE ALKE DAAY DCFI FSDV DLVP MDDR NLYR CGDQ PRHF AIAM D |
| Gene ID: | 8704 |
| Uniprot: | O60909 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 42kDa |
 | Western blot - B4GALT2 Polyclonal Antibody (CAB17573) |
| Synonyms: | B4Gal-T2, B4Gal-T3, beta4Gal-T2, B4GALT2 |
| Background: | This gene is one of seven beta-1, 4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1, 4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Protein Function: | B4GALT2: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose. Belongs to the glycosyltransferase 7 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - galactose; EC 2.4.1.22; Glycan Metabolism - keratan sulfate biosynthesis; EC 2.4.1.90; Glycan Metabolism - N-glycan biosynthesis; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.38; Transferase; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p34-p33 Cellular Component: Golgi membrane; integral to membrane Molecular Function:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; N-acetyllactosamine synthase activity; metal ion binding; lactose synthase activity; galactosyltransferase activity Biological Process: keratan sulfate metabolic process; cellular protein metabolic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; keratan sulfate biosynthetic process; protein amino acid N-linked glycosylation via asparagine; pathogenesis; post-translational protein modification |
| NCBI Summary: | This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | O60909 |
| NCBI GenInfo Identifier: | 13123972 |
| NCBI Gene ID: | 8704 |
| NCBI Accession: | O60909.1 |
| UniProt Secondary Accession: | O60909,O60511, Q4V9L9, Q5T4X5, Q5T4Y5, Q9BUP6, Q9NSY7 B3KTP0, B4DE14, D3DPY6, D3DPY7, |
| UniProt Related Accession: | O60909 |
| Molecular Weight: | 44,764 Da |
| NCBI Full Name: | Beta-1,4-galactosyltransferase 2 |
| NCBI Synonym Full Names: | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 |
| NCBI Official Symbol: | B4GALT2 |
| NCBI Official Synonym Symbols: | B4Gal-T2; B4Gal-T3; beta4Gal-T2 |
| NCBI Protein Information: | beta-1,4-galactosyltransferase 2; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; beta-1,4-GalTase 2; beta-4-GalT2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2 |
| UniProt Protein Name: | Beta-1,4-galactosyltransferase 2 |
| UniProt Synonym Protein Names: | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2Including the following 4 domains:Lactose synthase A protein (EC:2.4.1.22); N-acetyllactosamine synthase (EC:2.4.1.90)Alternative name(s):Nal synthase |
| Protein Family: | Beta-1,4-galactosyltransferase |
| UniProt Gene Name: | B4GALT2 |
| UniProt Entry Name: | B4GT2_HUMAN |
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