Anti-B3GNT6 Antibody (CAB14974)

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SKU:
CAB14974
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-B3GNT6 Antibody
Antibody SKU:CAB14974
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human B3GNT6 (NP_619651.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HT-29, Mouse stomach, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human B3GNT6 (NP_619651.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FLQA PRSP REER SPQE ETPE GPTD APAA DEPP SELV PGPP CVAN ASAN ATAD FEQL PARI QDFL RYRH CRHF PLLW DAPA KCAG GRGV FLLL AVKS APEH YERR ELIR RTWG QERS YGGR PVRR LFLL GTPG PEDE ARAE RLAE LVAL EARE HGDV LQWA FADT FLNL TLK
Gene ID:192134
Uniprot:Q6ZMB0
Cellular Location:Golgi apparatus membrane, Single-pass type II membrane protein
Calculated MW:29kDa/42kDa
Observed MW:43kDa
Synonyms:B3GNT6, B3Gn-T6, BGnT-6, beta-1, 3-Gn-T6
Background:The protein encoded by this gene is a beta-1, 3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans, which are important components of mucin-type glycoproteins.
UniProt Protein Function:B3GNT6: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.4.1.-; Membrane protein, integral; Transferase; Glycan Metabolism - O-glycan biosynthesis

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: Golgi membrane

Molecular Function:galactosyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

Biological Process: O-glycan processing

UniProt Code:Q6ZMB0
NCBI GenInfo Identifier:152033628
NCBI Gene ID:192134
NCBI Accession:Q6ZMB0.2
UniProt Secondary Accession:Q6ZMB0,Q6ZSC5, Q8TAZ4, Q8TDX1, E9PKS1,
UniProt Related Accession:Q6ZMB0
Molecular Weight:42,785 Da
NCBI Full Name:Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
NCBI Synonym Full Names:UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
NCBI Official Symbol:B3GNT6  
NCBI Official Synonym Symbols:BGnT-6; B3Gn-T6; beta3Gn-T6; beta-1,3-Gn-T6  
NCBI Protein Information:acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
UniProt Protein Name:Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
UniProt Synonym Protein Names:Core 3 synthase; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6; BGnT-6; Beta-1,3-Gn-T6; Beta-1,3-N-acetylglucosaminyltransferase 6; Beta3Gn-T6
Protein Family:Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
UniProt Gene Name:B3GNT6  
UniProt Entry Name:B3GN6_HUMAN
Anti-B3GNT6 Antibody (CAB14974)Western blot analysis of extracts of various cell lines, using B3GNT6 antibody (CAB14974) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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