Anti-ATP1B2 Antibody (CAB16768)
- SKU:
- CAB16768
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
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Description
| Antibody Name: | Anti-ATP1B2 Antibody |
| Antibody SKU: | CAB16768 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 68-290 of human ATP1B2 (NP_001669.3). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 68-290 of human ATP1B2 (NP_001669.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DHTP KYQD RLAT PGLM IRPK TENL DVIV NVSD TESW DQHV QKLN KFLE PYND SIQA QKND VCRP GRYY EQPD NGVL NYPK RACQ FNRT QLGN CSGI GDST HYGY STGQ PCVF IKMN RVIN FYAG ANQS MNVT CAGK RDED AENL GNFV MFPA NGNI DLMY FPYY GKKF HVNY TQPL VAVK FLNV TPNV EVNV ECRI NAAN IATD DERD KFAG RVAF KLRI NKT |
| Gene ID: | 482 |
| Uniprot: | P14415 |
| Cellular Location: | |
| Calculated MW: | 33kDa |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - ATP1B2 Polyclonal Antibody (CAB16768) |
| Synonyms: | ATP1B2, AMOG |
| Background: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ATP1B2: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complex Molecular Function:ATPase activator activity; ATPase binding; protein binding; sodium:potassium-exchanging ATPase activity Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport |
| NCBI Summary: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P14415 |
| NCBI GenInfo Identifier: | 125987795 |
| NCBI Gene ID: | 482 |
| NCBI Accession: | P14415.3 |
| UniProt Secondary Accession: | P14415,O60444, A0AV17, A8K278, D3DTQ2, |
| UniProt Related Accession: | P14415 |
| Molecular Weight: | 33,367 Da |
| NCBI Full Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
| NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit beta 2 |
| NCBI Official Symbol: | ATP1B2 |
| NCBI Official Synonym Symbols: | AMOG |
| NCBI Protein Information: | sodium/potassium-transporting ATPase subunit beta-2 |
| UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
| UniProt Synonym Protein Names: | Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2 |
| Protein Family: | Sodium/potassium-transporting ATPase |
| UniProt Gene Name: | ATP1B2 |
| UniProt Entry Name: | AT1B2_HUMAN |
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