Anti-ATG12 Antibody (RACO0207)
- SKU:
- RACO0207
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Product Name: | ATG12 Antibody |
| Product SKU: | RACO0207 |
| Size: | 50ul |
| Host Species: | Human |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | A synthesized peptide derived from human ATG12 |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Affinity-chromatography |
| Clonality: | Monoclonal |
| Isotype: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| Background: | Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. |
| Synonyms: | Ubiquitin-like protein ATG12, Autophagy-related protein 12, APG12-like, ATG12, APG12, APG12L |
| UniProt Protein Function: | ATG12: Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. Ubiquitous. Belongs to the ATG12 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Autophagy; Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 5q22.3 Cellular Component: cytosol; phagocytic vesicle membrane; pre-autophagosomal structure membrane Molecular Function:APG8 conjugating enzyme activity; protein binding Biological Process: autophagic vacuole formation; C-terminal protein lipidation; macroautophagy; mitochondrion degradation |
| NCBI Summary: | Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O94817 |
| NCBI GenInfo Identifier: | 17366241 |
| NCBI Gene ID: | 9140 |
| NCBI Accession: | O94817.1 |
| UniProt Secondary Accession: | O94817,Q6PJV2, |
| UniProt Related Accession: | O94817 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | Ubiquitin-like protein ATG12 |
| NCBI Synonym Full Names: | autophagy related 12 |
| NCBI Official Symbol: | ATG12Â Â |
| NCBI Official Synonym Symbols: | APG12; FBR93; APG12L; HAPG12Â Â |
| NCBI Protein Information: | ubiquitin-like protein ATG12 |
| UniProt Protein Name: | Ubiquitin-like protein ATG12 |
| UniProt Synonym Protein Names: | Autophagy-related protein 12; APG12-like |
| Protein Family: | Autophagy protein |
| UniProt Gene Name: | ATG12Â Â |
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