Anti-ATF7IP Antibody (CAB10446)

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SKU:
CAB10446
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-ATF7IP Antibody
Antibody SKU:CAB10446
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NEKD NKPE EEEQ VIHE DDER PSEK NEFS RRKR SKSE DMDN VQSK RRRY MEEE YEAE FQVK ITAK GDIN QKLQ KVIQ WLLE EKLC ALQC AVFD KTLA ELKT RVEK IECN KRHK TVLT ELQA KIAR LTKR FEAA KEDL KKRH EHPP NPPV SPGK TVND VNSN NNMS YRNA GTVR QMLE SKRN VSES APPS FQTP VNTV SSTN L
Gene ID:55729
Uniprot:Q6VMQ6
Cellular Location:Nucleus
Calculated MW:118kDa/136kDa/137kDa
Observed MW:
Synonyms:ATF7IP, AM, ATF-IP, MCAF, MCAF1, p621
Background:
UniProt Protein Function:ATF7IP: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. Belongs to the MCAF family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function:protein binding; ATPase activity; transcription corepressor activity

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; DNA methylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcriptional preinitiation complex assembly

NCBI Summary:ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
UniProt Code:Q6VMQ6
NCBI GenInfo Identifier:29611342
NCBI Gene ID:55729
NCBI Accession:AAO91864.1
UniProt Secondary Accession:Q6VMQ6,Q4G0T9, Q6P3T3, Q86XW5, Q9NVJ9, Q9NWC2, Q9Y4X8 F5GX74, G3V1U0,
UniProt Related Accession:Q6VMQ6
Molecular Weight:136,323 Da
NCBI Full Name:MBD1-containing chromatin associated factor
NCBI Synonym Full Names:activating transcription factor 7 interacting protein
NCBI Official Symbol:ATF7IP  
NCBI Official Synonym Symbols:AM; MCAF; p621; MCAF1; ATF-IP  
NCBI Protein Information:activating transcription factor 7-interacting protein 1
UniProt Protein Name:Activating transcription factor 7-interacting protein 1
UniProt Synonym Protein Names:ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621
UniProt Gene Name:ATF7IP  
UniProt Entry Name:MCAF1_HUMAN

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