Anti-ASCL4 Antibody (CAB14439)
- SKU:
- CAB14439
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-ASCL4 Antibody |
| Antibody SKU: | CAB14439 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human ASCL4 (NP_982260.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: | A-431, A-549, SGC-7901, 293T, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human ASCL4 (NP_982260.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMET RKPA ERLA LPYS LRTA PLGV PGTL PGLP RRDP LRVA LRLD AACW EWAR SGCA RGWQ YLPV PLDS AFEP AFLR KRNE RERQ RVRC VNEG YARL RDHL PREL ADKR LSKV ETLR AAID YIKH LQEL LERQ AWGL EGAA GAVP QRRA ECNS DGES KASS APSP SSEP EEGG |
| Gene ID: | 121549 |
| Uniprot: | Q6XD76 |
| Cellular Location: | Nucleus |
| Calculated MW: | 19kDa |
| Observed MW: | 19kDa |
| Synonyms: | ASCL4, HASH4, bHLHa44 |
| Background: |
| UniProt Protein Function: | ASCL4: Could be a transcriptional regulator involved in skin development. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q23.3 Cellular Component: nucleus Molecular Function:protein dimerization activity; DNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; skin development; transcription, DNA-dependent |
| NCBI Summary: | Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6XD76 |
| NCBI GenInfo Identifier: | 206597481 |
| NCBI Gene ID: | 121549 |
| NCBI Accession: | NP_982260.2 |
| UniProt Secondary Accession: | Q6XD76,Q7RTS2, |
| UniProt Related Accession: | Q6XD76 |
| Molecular Weight: | 19,253 Da |
| NCBI Full Name: | achaete-scute homolog 4 |
| NCBI Synonym Full Names: | achaete-scute family bHLH transcription factor 4 |
| NCBI Official Symbol: | ASCL4 |
| NCBI Official Synonym Symbols: | HASH4; bHLHa44 |
| NCBI Protein Information: | achaete-scute homolog 4; ASH-4; class II bHLH protein ASCL4; achaete-scute complex-like 4; achaete-scute-like protein 4; achaete-scute complex homolog 4; class A basic helix-loop-helix protein 44 |
| UniProt Protein Name: | Achaete-scute homolog 4 |
| UniProt Synonym Protein Names: | Achaete-scute-like protein 4; Class A basic helix-loop-helix protein 44; bHLHa44 |
| Protein Family: | Achaete-scute |
| UniProt Gene Name: | ASCL4 |
| UniProt Entry Name: | ASCL4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ASCL4 antibody (CAB14439) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using ASCL4 antibody (CAB14439) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using ASCL4 antibody (CAB14439) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using ASCL4 antibody (CAB14439) at dilution of 1:100 (40x lens). |
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