Anti-ASB7 Antibody (CAB16596)
- SKU:
- CAB16596
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-ASB7 Antibody |
| Antibody SKU: | CAB16596 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human ASB7 (NP_078984.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human ASB7 (NP_078984.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLHH HCRR NPEL QEEL QIQA AVAA GDVH TVRK MLEQ GYSP NGRD ANGW TLLH FSAA RGKE RCVR VFLE HGAD PTVK DLIG GFTA LHYA AMHG RARI ARLM LESE YRSD IINA KSND GWTP LHVA AHYG RDSF VRLL LEFK AEVD PLSD KGTT PLQL AIIR ERSS CVKI LLDH NANI DIQN GFLL RYAV IKSN HSYC RMFL QRGA DTNL GRLE DGQT PLHL SALR DDVL CARM LYNY GADT NTRN YEGQ TPLA VSIS ISGS SRPC LDFL QEVT SM |
| Gene ID: | 140460 |
| Uniprot: | Q9H672 |
| Cellular Location: | |
| Calculated MW: | 30kDa/36kDa |
| Observed MW: | 36kDa |
| Synonyms: | ASB7 |
| Background: | The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. |
| UniProt Protein Function: | ASB7: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 15q26.3 Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H672 |
| NCBI GenInfo Identifier: | 38372887 |
| NCBI Gene ID: | 140460 |
| NCBI Accession: | Q9H672.2 |
| UniProt Secondary Accession: | Q9H672,Q6GSJ6, Q7Z4S3, A8K1E5, |
| UniProt Related Accession: | Q9H672 |
| Molecular Weight: | 30,713 Da |
| NCBI Full Name: | Ankyrin repeat and SOCS box protein 7 |
| NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 7 |
| NCBI Official Symbol: | ASB7 |
| NCBI Protein Information: | ankyrin repeat and SOCS box protein 7 |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 7 |
| Protein Family: | Ankyrin repeat and SOCS box protein |
| UniProt Gene Name: | ASB7 |
| UniProt Entry Name: | ASB7_HUMAN |
 | Western blot analysis of extracts of mouse brain, using ASB7 antibody (CAB16596) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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