Anti-ARPC2 Antibody (CAB10791)
- SKU:
- CAB10791
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ARPC2 Antibody |
| Antibody SKU: | CAB10791 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ARPC2 (NP_690601.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375, U-87MG, HT-29, SGC-7901, Mouse heart, Mouse lung, Mouse spleen, Mouse thymus, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ARPC2 (NP_690601.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MILL EVNN RIIE ETLA LKFE NAAA GNKP EAVE VTFA DFDG VLYH ISNP NGDK TKVM VSIS LKFY KELQ AHGA DELL KRVY GSFL VNPE SGYN VSLL YDLE NLPA SKDS IVHQ AGML KRNC FASV FEKY FQFQ EEGK EGEN RAVI HYRD DETM YVES KKDR VTVV FSTV FKDD DDVV IGKV FMQE FKEG RRAS HTAP QVLF SHRE PPLE LKDT DAAV GDNI GYIT FVLF PRHT NASA RDNT INLI HTFR DYLH YHIK CSKA YIHT RMRA KTSD FLKV LNRA RPDA EKKE MKTI TGKT FSSR |
| Gene ID: | 10109 |
| Uniprot: | O15144 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, cytoskeleton, synapse, synaptosome |
| Calculated MW: | 34kDa |
| Observed MW: | 34kDa |
| Synonyms: | ARPC2, ARC34, PNAS-139, PRO2446, p34-Arc |
| Background: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. |
| UniProt Protein Function: | ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q36.1 Cellular Component: Golgi apparatus; Arp2/3 protein complex; neuron projection; focal adhesion; cytoplasm; leading edge; plasma membrane; synapse; cytosol; endosome; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; kinesin binding Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility |
| NCBI Summary: | This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15144 |
| NCBI GenInfo Identifier: | 3121764 |
| NCBI Gene ID: | 10109 |
| NCBI Accession: | O15144.1 |
| UniProt Secondary Accession: | O15144,Q92801, Q9P1D4, |
| UniProt Related Accession: | O15144 |
| Molecular Weight: | 34,333 Da |
| NCBI Full Name: | Actin-related protein 2/3 complex subunit 2 |
| NCBI Synonym Full Names: | actin related protein 2/3 complex, subunit 2, 34kDa |
| NCBI Official Symbol: | ARPC2 |
| NCBI Official Synonym Symbols: | ARC34; PRO2446; p34-Arc; PNAS-139 |
| NCBI Protein Information: | actin-related protein 2/3 complex subunit 2; ARP2/3 protein complex subunit 34; arp2/3 complex 34 kDa subunit |
| UniProt Protein Name: | Actin-related protein 2/3 complex subunit 2 |
| UniProt Synonym Protein Names: | Arp2/3 complex 34 kDa subunit; p34-ARC |
| UniProt Gene Name: | ARPC2 |
| UniProt Entry Name: | ARPC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ARPC2 antibody (CAB10791) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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