Anti-ARHGAP4 Antibody (CAB18338)
- SKU:
- CAB18338
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-ARHGAP4 Antibody |
| Antibody SKU: | CAB18338 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human ARHGAP4. |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat |
| Immunogen: | A synthetic peptide of human ARHGAP4. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 393 |
| Uniprot: | P98171 |
| Cellular Location: | |
| Calculated MW: | 105kDa/109kDa |
| Observed MW: | 105kDa |
 | Western blot - ARHGAP4 Rabbit pAb (CAB18338) |
| Synonyms: | C1, RGC1, RhoGAP4, SrGAP4, p115, ARHGAP4 |
| Background: | This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ARHGAP4: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytoplasm; cytosol Molecular Function:GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rac GTPase binding; Rho guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity Biological Process: cytoskeleton organization and biogenesis; negative regulation of cell migration; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; Rho protein signal transduction |
| NCBI Summary: | This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P98171 |
| NCBI GenInfo Identifier: | 258613907 |
| NCBI Gene ID: | 393 |
| NCBI Accession: | NP_001158213.1 |
| UniProt Secondary Accession: | P98171,Q14144, Q86UY3, |
| UniProt Related Accession: | P98171 |
| Molecular Weight: | 109,393 Da |
| NCBI Full Name: | rho GTPase-activating protein 4 isoform 1 |
| NCBI Synonym Full Names: | Rho GTPase activating protein 4 |
| NCBI Official Symbol: | ARHGAP4 |
| NCBI Official Synonym Symbols: | C1; RGC1; p115; SrGAP4; RhoGAP4 |
| NCBI Protein Information: | rho GTPase-activating protein 4 |
| UniProt Protein Name: | Rho GTPase-activating protein 4 |
| UniProt Synonym Protein Names: | Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4; p115 |
| UniProt Gene Name: | ARHGAP4 |
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