Anti-Aquaporin-9 Antibody (CAB8540)
- SKU:
- CAB8540
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Aquaporin-9 Antibody |
| Antibody SKU: | CAB8540 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human AQP9 (NP_066190.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, 293T, Mouse liver, Mouse skeletal muscle, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human AQP9 (NP_066190.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SRGR FGGV ITIN VGFS MAVA MAIY VAGG VSGG HINP AVSL AMCL FGRM KWFK LPFY VGAQ FLGA FVGA ATVF GIYY DGLM SFAG GKLL IVGE NATA HIFA T |
| Gene ID: | 366 |
| Uniprot: | O43315 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 31kDa |
| Observed MW: | 38kDa |
| Synonyms: | AQP9, AQP-9, HsT17287, SSC1, T17287 |
| Background: | The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | AQP9: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family; Channel, misc. Chromosomal Location of Human Ortholog: 15q Cellular Component: intracellular membrane-bound organelle; basolateral plasma membrane; integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:purine transmembrane transporter activity; water transporter activity; amine transmembrane transporter activity; pyrimidine transmembrane transporter activity; urea transmembrane transporter activity; polyol transmembrane transporter activity; carboxylic acid transmembrane transporter activity; water channel activity; porin activity; glycerol channel activity Biological Process: polyol transport; glycerol transport; cellular water homeostasis; metabolic process; amine transport; water transport; excretion; response to osmotic stress; carboxylic acid transport; purine transport; water homeostasis; response to mercury ion; response to organic substance; transport; pyrimidine transport; canalicular bile acid transport; immune response; transmembrane transport |
| NCBI Summary: | The aquaporins are a family of water-selective membrane channels. The protein encoded by this gene allows passage of a wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43315 |
| NCBI GenInfo Identifier: | 157266307 |
| NCBI Gene ID: | 366 |
| NCBI Accession: | NP_066190.2 |
| UniProt Secondary Accession: | O43315,Q9NP32, |
| UniProt Related Accession: | O43315 |
| Molecular Weight: | 31,431 Da |
| NCBI Full Name: | aquaporin-9 |
| NCBI Synonym Full Names: | aquaporin 9 |
| NCBI Official Symbol: | AQP9 |
| NCBI Official Synonym Symbols: | SSC1; AQP-9; HsT17287 |
| NCBI Protein Information: | aquaporin-9; aquaglyceroporin-9; small solute channel 1 |
| UniProt Protein Name: | Aquaporin-9 |
| UniProt Synonym Protein Names: | Aquaglyceroporin-9; Small solute channel 1 |
| Protein Family: | Aquaporin |
| UniProt Gene Name: | AQP9 |
| UniProt Entry Name: | AQP9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AQP9 antibody (CAB8540) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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