Anti-Aquaporin 4 Antibody (CAB5665)
- SKU:
- CAB5665
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-Aquaporin 4 Antibody |
| Antibody SKU: | CAB5665 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-323 of human Aquaporin 4 (NP_001641.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-323 of human Aquaporin 4 (NP_001641.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AGGL YEYV FCPD VEFK RRFK EAFS KAAQ QTKG SYME VEDN RSQV ETDD LILK PGVV HVID VDRG EEKK GKDQ SGEV LSSV |
| Gene ID: | 361 |
| Uniprot: | P55087 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 32kDa/34kDa |
| Observed MW: | 30kDa |
| Synonyms: | AQP4, MIWC, WCH4, aquaporin-4 |
| Background: | This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. |
| UniProt Protein Function: | AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described |
| UniProt Protein Details: | Protein type:Transporter, aquaporin family; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 18q11.2-q12.1 Cellular Component: basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; plasma membrane Molecular Function:glycerol channel activity; water channel activity; water transporter activity Biological Process: glycerol transport; multicellular organismal water homeostasis; renal water homeostasis; transmembrane transport; transport; water transport |
| NCBI Summary: | This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015] |
| UniProt Code: | P55087 |
| NCBI GenInfo Identifier: | 2506859 |
| NCBI Gene ID: | 361 |
| NCBI Accession: | P55087.2 |
| UniProt Secondary Accession: | P55087,P78564, |
| UniProt Related Accession: | P55087 |
| Molecular Weight: | 32,300 Da |
| NCBI Full Name: | Aquaporin-4 |
| NCBI Synonym Full Names: | aquaporin 4 |
| NCBI Official Symbol: | AQP4 |
| NCBI Official Synonym Symbols: | MIWC; WCH4 |
| NCBI Protein Information: | aquaporin-4 |
| UniProt Protein Name: | Aquaporin-4 |
| UniProt Synonym Protein Names: | Mercurial-insensitive water channel; MIWC; WCH4 |
| Protein Family: | Aquaporin |
| UniProt Gene Name: | AQP4 |
| UniProt Entry Name: | AQP4_HUMAN |
 | Western blot - Aquaporin 4 Polyclonal Antibody (CAB5665) |
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