Anti-APOC2 Antibody (CAB1772)
- SKU:
- CAB1772
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-APOC2 Antibody |
| Antibody SKU: | CAB1772 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human APOC2 (NP_000474.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | Rat liver, Rat plasma |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human APOC2 (NP_000474.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGTR LLPA LFLV LLVL GFEV QGTQ QPQQ DEMP SPTF LTQV KESL SSYW ESAK TAAQ NLYE KTYL PAVD EKLR DLYS KSTA AMST YTGI FTDQ VLSV LKGE E |
| Gene ID: | 344 |
| Uniprot: | P02655 |
| Cellular Location: | Secreted |
| Calculated MW: | 11kDa |
| Observed MW: | 11KDa |
| Synonyms: | APOC2, APO-CII, APOC-II |
| Background: | This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. |
| UniProt Protein Function: | APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: chylomicron; early endosome; extracellular region; extracellular space Molecular Function:lipase inhibitor activity; lipid binding; phospholipase activator activity; phospholipase binding; protein homodimerization activity Biological Process: cholesterol efflux; cholesterol homeostasis; lipoprotein metabolic process; negative regulation of cholesterol transport; negative regulation of lipid metabolic process; negative regulation of receptor-mediated endocytosis; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; retinoid metabolic process; reverse cholesterol transport Disease: Apolipoprotein C-ii Deficiency |
| NCBI Summary: | This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | P02655 |
| NCBI GenInfo Identifier: | 114022 |
| NCBI Gene ID: | 344 |
| NCBI Accession: | P02655.1 |
| UniProt Secondary Accession: | P02655,Q9BS39, Q9UDE3, Q9UNK3, C0JYY4, |
| UniProt Related Accession: | P02655 |
| Molecular Weight: | 11,284 Da |
| NCBI Full Name: | Apolipoprotein C-II |
| NCBI Synonym Full Names: | apolipoprotein C2 |
| NCBI Official Symbol: | APOC2 |
| NCBI Official Synonym Symbols: | APO-CII; APOC-II |
| NCBI Protein Information: | apolipoprotein C-II |
| UniProt Protein Name: | Apolipoprotein C-II |
| UniProt Synonym Protein Names: | Apolipoprotein C2 |
| Protein Family: | Apolipoprotein |
| UniProt Gene Name: | APOC2 |
| UniProt Entry Name: | APOC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using APOC2 antibody (CAB1772) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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