Anti-APOBEC1 Antibody (CAB16756)
- SKU:
- CAB16756
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-APOBEC1 Antibody |
| Antibody SKU: | CAB16756 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human APOBEC1 (NP_001291495). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human APOBEC1 (NP_001291495). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTSE KGPS TGDP TLRR RIEP WEFD VFYD PREL RKEA CLLY EIKW GMSR KIWR SSGK NTTN HVEV NFIK KFTS ERDF HPSM |
| Gene ID: | 339 |
| Uniprot: | P41238 |
| Cellular Location: | |
| Calculated MW: | 28kDa |
| Observed MW: | Refer to figures |
| Synonyms: | APOBEC1, APOBEC-1, BEDP, CDAR1, HEPR |
| Background: | This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Ref.8 |
| UniProt Protein Details: | Cofactor: Zinc By similarity. Subunit structure: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP. Ref.6 Ref.7 Subcellular location: Cytoplasm Ref.9. Tissue specificity: Expressed exclusively in the small intestine. Sequence similarities: Belongs to the cytidine and deoxycytidylate deaminase family. |
| NCBI Summary: | This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] |
| UniProt Code: | P41238 |
| NCBI GenInfo Identifier: | 61743957 |
| NCBI Gene ID: | 339 |
| NCBI Accession: | NP_001635 |
| UniProt Related Accession: | P41238 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | C->U-editing enzyme APOBEC-1 isoform a |
| NCBI Synonym Full Names: | apolipoprotein B mRNA editing enzyme catalytic subunit 1 |
| NCBI Official Symbol: | APOBEC1 |
| NCBI Official Synonym Symbols: | BEDP; HEPR; CDAR1; APOBEC-1 |
| NCBI Protein Information: | C->U-editing enzyme APOBEC-1 |
| UniProt Protein Name: | C->U-editing enzyme APOBEC-1 |
| UniProt Synonym Protein Names: | Apolipoprotein B mRNA-editing enzyme 1; HEPR |
| Protein Family: | APOBEC1 complementation factor |
| UniProt Gene Name: | APOBEC1 |
| UniProt Entry Name: | ABEC1_HUMAN |
 | Western blot analysis of extracts of mouse spleen, using APOBEC1 antibody (CAB16756) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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