Anti-AOAH Antibody (CAB10366)
- SKU:
- CAB10366
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-AOAH Antibody |
| Antibody SKU: | CAB10366 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 306-575 of human AOAH (NP_001628.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 306-575 of human AOAH (NP_001628.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GFLD STVG IKEK SIYL RLWK RNHC NHRD YQNI SRNG ASSR NLKK FIES LSRN KVLD YPAI VIYA MIGN DVCS GKSD PVPA MTTP EKLY SNVM QTLK HLNS HLPN GSHV ILYG LPDG TFLW DNLH NRYH PLGQ LNKD MTYA QLYS FLNC LQVS PCHG WMSS NKTL RTLT SERA EQLS NTLK KIAA SEKF TNFN LFYM DFAF HEII QEWQ KRGG QPWQ LIEP VDGF HPNE VALL LLAD HFWK KVQL QWPQ ILGK ENPF NPQI KQVF GDQG GH |
| Gene ID: | 313 |
| Uniprot: | P28039 |
| Cellular Location: | Secreted |
| Calculated MW: | 61kDa/65kDa |
| Observed MW: | 75kDa |
| Synonyms: | AOAH |
| Background: | This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | AOAH: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.1.77; Lipase; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7p14.2 Molecular Function:catalytic activity; lipoprotein lipase activity Biological Process: inflammatory response; lipid metabolic process |
| NCBI Summary: | This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010] |
| UniProt Code: | P28039 |
| NCBI GenInfo Identifier: | 113976 |
| NCBI Gene ID: | 313 |
| NCBI Accession: | P28039.1 |
| UniProt Secondary Accession: | P28039,Q53F13, A4D1Y5, B7Z490, |
| UniProt Related Accession: | P28039 |
| Molecular Weight: | 61,647 Da |
| NCBI Full Name: | Acyloxyacyl hydrolase |
| NCBI Synonym Full Names: | acyloxyacyl hydrolase |
| NCBI Official Symbol: | AOAH |
| NCBI Protein Information: | acyloxyacyl hydrolase |
| UniProt Protein Name: | Acyloxyacyl hydrolase |
| Protein Family: | Acyloxyacyl hydrolase |
| UniProt Gene Name: | AOAH |
| UniProt Entry Name: | AOAH_HUMAN |
 | Western blot analysis of extracts of BxPC-3 cells, using AOAH antibody (CAB10366) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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