| Background: | The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| NCBI Summary: | The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08758 |
| NCBI GenInfo Identifier: | 113960 |
| NCBI Gene ID: | 308 |
| NCBI Accession: | P08758.2 |
| UniProt Secondary Accession: | P08758,Q6FHB3, Q6FI16, Q8WV69, Q9UDH9, D3DNW7, |
| UniProt Related Accession: | P08758 |
| Molecular Weight: | 35,937 Da |
| NCBI Full Name: | Annexin A5 |
| NCBI Synonym Full Names: | annexin A5 |
| NCBI Official Symbol: | ANXA5 |
| NCBI Official Synonym Symbols: | PP4; ANX5; ENX2; RPRGL3; HEL-S-7 |
| NCBI Protein Information: | annexin A5 |
| UniProt Protein Name: | Annexin A5 |
| UniProt Synonym Protein Names: | Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha |
| Protein Family: | Annexin |
| UniProt Gene Name: | ANXA5 |
| UniProt Entry Name: | ANXA5_HUMAN |
