Anti-ANKLE2 Antibody (CAB17654)

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SKU:
CAB17654
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-ANKLE2 Antibody
Antibody SKU:CAB17654
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human ANKLE2 (NP_055929.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Jurkat, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human ANKLE2 (NP_055929.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CRYN VMHV AAKE NQAS ICQL TLDV LENP DFMR LMYP DDDE AMLQ KRIR YVVD LYLN TPDK MGYD TPLH FACK FGNA DVVN VLSS HHLI VKNS RNKY DKTP E
Gene ID:23141
Uniprot:Q86XL3
Cellular Location:
Calculated MW:
Observed MW:104kDa
Anti-ANKLE2 Antibody (CAB17654)Western blot - ANKLE2 Rabbit pAb (CAB17654)
Synonyms:KIAA0692, LEMD7, Lem4, MCPH16, ANKLE2
Background:This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
UniProt Protein Function:ANKLE2: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Belongs to the ANKLE2 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: endoplasmic reticulum membrane; membrane; integral to endoplasmic reticulum membrane

Molecular Function:protein binding; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity

Biological Process: mitosis; mitotic nuclear envelope reassembly; cell division; regulation of catalytic activity; negative regulation of phosphorylation; mitotic cell cycle; positive regulation of protein amino acid dephosphorylation

NCBI Summary:This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
UniProt Code:Q86XL3
NCBI GenInfo Identifier:148664230
NCBI Gene ID:23141
NCBI Accession:NP_055929.1
UniProt Secondary Accession:Q86XL3,O75176, Q6P6A5, Q8TAZ9, Q96DH4, A8KAG3, B3KN97 B3KSF8,
UniProt Related Accession:Q86XL3
Molecular Weight:31,982 Da
NCBI Full Name:ankyrin repeat and LEM domain-containing protein 2
NCBI Synonym Full Names:ankyrin repeat and LEM domain containing 2
NCBI Official Symbol:ANKLE2  
NCBI Official Synonym Symbols:Lem4; LEMD7; KIAA0692  
NCBI Protein Information:ankyrin repeat and LEM domain-containing protein 2
UniProt Protein Name:Ankyrin repeat and LEM domain-containing protein 2
UniProt Synonym Protein Names:LEM domain-containing protein 4
Protein Family:Ankyrin repeat and LEM domain-containing protein
UniProt Gene Name:ANKLE2  
UniProt Entry Name:ANKL2_HUMAN

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