Anti-ANAPC2 Antibody (CAB8066)
- SKU:
- CAB8066
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | ANAPC2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8066 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ANAPC2 (NP_037498.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brian, Mouse kidney, Rat brian, Rat kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ANAPC2 (NP_037498.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YISA IKAL RVLD PSMV ILEV ACEP IRRY LRTR EDTV RQIV AGLT GDSD GTGD LAVE LSKT DPAS LETG QDSE DDSG EPED WVPD PVDA DPGK SSSK RRSS D |
| Gene ID: | 29882 |
| Uniprot: | Q9UJX6 |
| Cellular Location: | |
| Calculated MW: | 93kDa |
| Observed MW: | 102kDa |
| Synonyms: | ANAPC2, APC2 |
| Background: | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. |
| NCBI Summary: | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UJX6 |
| NCBI GenInfo Identifier: | 37537863 |
| NCBI Gene ID: | 29882 |
| NCBI Accession: | Q9UJX6.1 |
| UniProt Related Accession: | Q9UJX6 |
| Molecular Weight: | 93kDa |
| NCBI Full Name: | Anaphase-promoting complex subunit 2 |
| NCBI Synonym Full Names: | anaphase promoting complex subunit 2 |
| NCBI Official Symbol: | ANAPC2 |
| NCBI Official Synonym Symbols: | APC2 |
| NCBI Protein Information: | anaphase-promoting complex subunit 2 |
| UniProt Protein Name: | Anaphase-promoting complex subunit 2 |
| UniProt Synonym Protein Names: | Cyclosome subunit 2 |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | ANAPC2 |
| UniProt Entry Name: | ANC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ANAPC2 antibody (CAB8066) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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