Anti-AMPD1 Antibody (CAB3584)
- SKU:
- CAB3584
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-AMPD1 Antibody |
| Antibody SKU: | CAB3584 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-260 of human AMPD1 (NP_001166097.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375, SKOV3, A-549, Mouse heart, Mouse lung, Rat skeletal muscle, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-260 of human AMPD1 (NP_001166097.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AEKV FASE VKDE GGRQ EISP FDVD EICP ISHH EMQA HIFH LETL STST EARR KKRF QGRK TVNL SIPL SETS STKL SHID EYIS SSPT YQTV PDFQ RVQI TGDY ASGV TVED FEIV CKGL YRAL CIRE KYMQ KSFQ RFPK TPSK YLRN IDGE AWVA NESF YPVF TPPV KKGE DPFR TDNL PENL GYHL KMKD GVVY VYPN EAAV SKDE PKP |
| Gene ID: | 270 |
| Uniprot: | P23109 |
| Cellular Location: | |
| Calculated MW: | 89kDa/90kDa |
| Observed MW: | 80kDa |
| Synonyms: | AMPD1, MAD, MADA, MMDD |
| Background: | Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
| UniProt Code: | P23109 |
| NCBI GenInfo Identifier: | 384872309 |
| NCBI Gene ID: | 270 |
| NCBI Accession: | P23109.2 |
| UniProt Secondary Accession: | P23109,Q5TF00, Q5TF02, A8K5N4, B2RAM1, F2Z3B3, |
| UniProt Related Accession: | P23109 |
| Molecular Weight: | 747 |
| NCBI Full Name: | AMP deaminase 1 |
| NCBI Synonym Full Names: | adenosine monophosphate deaminase 1 |
| NCBI Official Symbol: | AMPD1 |
| NCBI Official Synonym Symbols: | MAD; MADA; MMDD |
| NCBI Protein Information: | AMP deaminase 1; AMPD; skeletal muscle AMPD; myoadenylate deaminase; adenosine monophosphate deaminase-1 (muscle); adenosine monophosphate deaminase 1 (isoform M) |
| UniProt Protein Name: | AMP deaminase 1 |
| UniProt Synonym Protein Names: | AMP deaminase isoform M; Myoadenylate deaminase |
| Protein Family: | AMP deaminase |
| UniProt Gene Name: | AMPD1 |
| UniProt Entry Name: | AMPD1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AMPD1 antibody (CAB3584) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of NIH/3T3 cells using AMPD1 Rabbit pAb (CAB3584) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using AMPD1 Rabbit pAb (CAB3584) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of C6 cells using AMPD1 Rabbit pAb (CAB3584) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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