Anti-alpha-Actin-1 (ACTA1) Antibody (CAB2280)

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SKU:
CAB2280
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ACTA
ASMA
CFTD
CFTD1
CFTDM
MPFD
NEM1
NEM2
NEM3
SHPM
Frequently bought together:

Description

Product Name:?-Actin-1 (ACTA1) Rabbit mAb
Product Code:CAB2280
Size:20uL, 50uL, 100uL
Synonyms:ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3, SHPM
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ?-Actin-1 (ACTA1)
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, A-431, C6, Mouse lung, Mouse brain, Mouse heart, Rat heart
Immunogen:A synthesized peptide derived from human ?-Actin-1 (ACTA1)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:58
Uniprot:P68133
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:42kDa
Observed MW:42kDa
UniProt Protein Function:ACTA1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family.
UniProt Protein Details:

Protein type:Cell development/differentiation; Motility/polarity/chemotaxis; Contractile; Cytoskeletal

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: extracellular space; sarcomere; stress fiber; actin filament; cytosol; striated muscle thin filament; actin cytoskeleton

Molecular Function:protein binding; myosin binding; structural constituent of cytoskeleton; ADP binding; ATP binding

Biological Process: skeletal muscle fiber adaptation; muscle contraction; muscle thin filament assembly; response to steroid hormone stimulus; response to mechanical stimulus; response to lithium ion; response to extracellular stimulus; skeletal muscle fiber development; cell growth; muscle filament sliding

Disease: Nemaline Myopathy 3; Myopathy, Congenital, With Fiber-type Disproportion

NCBI Summary:The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]
UniProt Code:P68133
NCBI GenInfo Identifier:4501881
NCBI Gene ID:58
NCBI Accession:NP_001091.1
UniProt Secondary Accession:P68133,P02568, P99020, Q5T8M9,
UniProt Related Accession:P68133
Molecular Weight:42,051 Da
NCBI Full Name:actin, alpha skeletal muscle
NCBI Synonym Full Names:actin, alpha 1, skeletal muscle
NCBI Official Symbol:ACTA1  
NCBI Official Synonym Symbols:ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM  
NCBI Protein Information:actin, alpha skeletal muscle; nemaline myopathy type 3
UniProt Protein Name:Actin, alpha skeletal muscle
UniProt Synonym Protein Names:Alpha-actin-1
UniProt Gene Name:ACTA1  
UniProt Entry Name:ACTS_HUMAN

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