| UniProt Protein Function: | Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N1-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:22055184, PubMed:16858410). |
| NCBI Summary: | The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96Q83 |
| NCBI GenInfo Identifier: | 74752087 |
| NCBI Gene ID: | 221120 |
| NCBI Accession: | Q96Q83.1 |
| UniProt Secondary Accession: | Q96Q83,Q3SYI0, Q6NX57, Q96BU8, A6NDJ1, |
| UniProt Related Accession: | Q96Q83 |
| Molecular Weight: | 19,310 Da |
| NCBI Full Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
| NCBI Synonym Full Names: | alkB homolog 3, alpha-ketoglutaratedependent dioxygenase |
| NCBI Official Symbol: | ALKBH3 |
| NCBI Official Synonym Symbols: | ABH3; PCA1; DEPC1; hABH3; DEPC-1 |
| NCBI Protein Information: | alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
| UniProt Protein Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
| UniProt Synonym Protein Names: | Alkylated DNA repair protein alkB homolog 3 |
| UniProt Gene Name: | ALKBH3 |
