Anti-ALAS1 Antibody (CAB4817)
- SKU:
- CAB4817
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ALAS
- ALAS-H
- ALAS3
- ALASH
- MIG4
Frequently bought together:
Description
| Product Name: | ALAS1 Rabbit mAb |
| Product Code: | CAB4817 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ALAS, ALAS-H, ALAS3, ALASH, MIG4 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ALAS1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, HepG2, SKOV3 |
| Immunogen: | A synthesized peptide derived from human ALAS1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 211 |
| Uniprot: | P13196 |
| Calculated MW: | 71kDa |
| Observed MW: | 70KDa |
| UniProt Protein Function: | ALAS1: the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
| UniProt Protein Details: | Protein type:EC 2.3.1.37; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Transferase Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm Molecular Function:5-aminolevulinate synthase activity; pyridoxal phosphate binding Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process |
| NCBI Summary: | This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
| UniProt Code: | P13196 |
| NCBI GenInfo Identifier: | 122824 |
| NCBI Gene ID: | 211 |
| NCBI Accession: | P13196.2 |
| UniProt Related Accession: | P13196 |
| Molecular Weight: | 640 |
| NCBI Full Name: | 5-aminolevulinate synthase, nonspecific, mitochondrial |
| NCBI Synonym Full Names: | 5'-aminolevulinate synthase 1 |
| NCBI Official Symbol: | ALAS1 |
| NCBI Official Synonym Symbols: | ALAS; MIG4; ALAS3; ALASH |
| NCBI Protein Information: | 5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; delta-ALA synthase 1; migration-inducing protein 4; 5-aminolevulinic acid synthase 1; delta-aminolevulinate synthase 1; aminolevulinate, delta-, synthase 1 |
| UniProt Protein Name: | 5-aminolevulinate synthase, nonspecific, mitochondrial |
| UniProt Synonym Protein Names: | 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1 |
| Protein Family: | Alanine--tRNA ligase |
| UniProt Gene Name: | ALAS1 |
| UniProt Entry Name: | HEM1_HUMAN |
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