Anti-ALAS1 Antibody (CAB13462)
- SKU:
- CAB13462
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-ALAS1 Antibody |
| Antibody SKU: | CAB13462 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALAS1 (NP_954635.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALAS1 (NP_954635.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MESV VRRC PFLS RVPQ AFLQ KAGK SLLF YAQN CPKM MEVG AKPA PRAL STAA VHYQ QIKE TPPA SEKD KTAK AKVQ QTPD GSQQ SPDG TQLP SGHP LPAT SQGT ASKC PFLA AQMN QRGS SVFC KASL ELQE DVQE MNAV RKEV AETS AGPS VVSV KTDG GDPS GLLK NFQD IMQK QRPE RVSH LLQD NLPK SVST FQYD RFFE KKID EKKN DHTY RVFK TVNR RAHI FPMA DDYS DSLI TKKQ VSVW CS |
| Gene ID: | 211 |
| Uniprot: | P13196 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 12kDa/70kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ALAS1, ALAS, ALAS-H, ALAS3, ALASH, MIG4 |
| Background: | This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | ALAS1: the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
| UniProt Protein Details: | Protein type:EC 2.3.1.37; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Transferase Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm Molecular Function:5-aminolevulinate synthase activity; pyridoxal phosphate binding Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process |
| NCBI Summary: | This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
| UniProt Code: | P13196 |
| NCBI GenInfo Identifier: | 122824 |
| NCBI Gene ID: | 211 |
| NCBI Accession: | P13196.2 |
| UniProt Related Accession: | P13196 |
| Molecular Weight: | 640 |
| NCBI Full Name: | 5-aminolevulinate synthase, nonspecific, mitochondrial |
| NCBI Synonym Full Names: | 5'-aminolevulinate synthase 1 |
| NCBI Official Symbol: | ALAS1 |
| NCBI Official Synonym Symbols: | ALAS; MIG4; ALAS3; ALASH |
| NCBI Protein Information: | 5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; delta-ALA synthase 1; migration-inducing protein 4; 5-aminolevulinic acid synthase 1; delta-aminolevulinate synthase 1; aminolevulinate, delta-, synthase 1 |
| UniProt Protein Name: | 5-aminolevulinate synthase, nonspecific, mitochondrial |
| UniProt Synonym Protein Names: | 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1 |
| Protein Family: | Alanine--tRNA ligase |
| UniProt Gene Name: | ALAS1 |
| UniProt Entry Name: | HEM1_HUMAN |
 | Immunofluorescence analysis of HeLa cells using ALAS1 antibody (CAB13462). Blue: DAPI for nuclear staining. |
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