Anti-AKR7A3 Antibody (CAB8194)
- SKU:
- CAB8194
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | AKR7A3 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8194 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human AKR7A3 (NP_036199.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HT-29, Mouse kidney, Mouse liver, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human AKR7A3 (NP_036199.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSRQ LSRA RPAT VLGA MEMG RRMD APTS AAVT RAFL ERGH TEID TAFV YSEG QSET ILGG LGLR LGGS DCRV KIDT KAIP LFGN SLKP DSLR FQLE TSLK RLQC PRVD LFYL HMPD HSTP VEET LRAC HQLH QEGK FVEL GLSN YAAW EVAE ICTL CKSN GWIL PTVY QGMY NAIT RQVE TELF PCLR HFGL RFYA FNPL AGGL LTGK YKYE DKNG KQPV GRFF GNTW AEMY RNRY WKEH HFEG IALV EKAL QAAY GASA PSMT SATL RWMY HHSQ LQGA HGDA VILG MSSL EQLE QNLA AAEE GPLE PAVV DAFN QAWH LVTH ECPN YFR |
| Gene ID: | 22977 |
| Uniprot: | O95154 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 37kDa |
| Observed MW: | 37kDa |
| Synonyms: | AKR7A3, AFAR2 |
| Background: |
| UniProt Protein Function: | AKR7A3: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.-.-.- Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: cytosol Molecular Function:aldo-keto reductase activity; electron carrier activity; protein binding Biological Process: aldehyde metabolic process; xenobiotic metabolic process |
| NCBI Summary: | Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004] |
| UniProt Code: | O95154 |
| NCBI GenInfo Identifier: | 13123960 |
| NCBI Gene ID: | 22977 |
| NCBI Accession: | O95154.2 |
| UniProt Secondary Accession: | O95154,Q86SR4, Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3, |
| UniProt Related Accession: | O95154 |
| Molecular Weight: | 37,206 Da |
| NCBI Full Name: | Aflatoxin B1 aldehyde reductase member 3 |
| NCBI Synonym Full Names: | aldo-keto reductase family 7 member A3 |
| NCBI Official Symbol: | AKR7A3 |
| NCBI Official Synonym Symbols: | AFAR2 |
| NCBI Protein Information: | aflatoxin B1 aldehyde reductase member 3 |
| UniProt Protein Name: | Aflatoxin B1 aldehyde reductase member 3 |
| UniProt Synonym Protein Names: | AFB1 aldehyde reductase 2; AFB1-AR 2 |
| Protein Family: | Aflatoxin B1 aldehyde reductase |
| UniProt Gene Name: | AKR7A3 |
| UniProt Entry Name: | ARK73_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AKR7A3 antibody (CAB8194) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using AKR7A3 antibody (CAB8194) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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