Anti-AKR1B10 Antibody (CAB7823)
- SKU:
- CAB7823
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-AKR1B10 Antibody |
| Antibody SKU: | CAB7823 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B10 (NP_064695.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, Mouse small intestine, Mouse stomach, Mouse liver, Mouse kidney, Rat small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B10 (NP_064695.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATF VELS TKAK MPIV GLGT WKSP LGKV KEAV KVAI DAGY RHID CAYV YQNE HEVG EAIQ EKIQ EKAV KRED LFIV SKLW PTFF ERPL VRKA FEKT LKDL KLSY LDVY LIHW PQGF KSGD DLFP KDDK GNAI GGKA TFLD AWEA MEEL VDEG LVKA LGVS NFSH FQIE KLLN KPGL KYKP VTNQ VECH PYLT QEKL IQYC HSKG ITVT AYSP LGSP DRPW AKPE DPSL LEDP KIKE IAAK HKKT AAQV LIRF HIQR NVIV IPKS VTPA RIVE NIQV FDFK LSDE EMAT ILSF NRNW RACN VLQS SHLE DYPF NAEY |
| Gene ID: | 57016 |
| Uniprot: | O60218 |
| Cellular Location: | Lysosome, Secreted |
| Calculated MW: | 36kDa |
| Observed MW: | 36kDa |
| Synonyms: | AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI |
| Background: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. |
| UniProt Protein Function: | AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Belongs to the aldo/keto reductase family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - linoleic acid; Oxidoreductase; EC 1.1.1.21; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.- Chromosomal Location of Human Ortholog: 7q33 Cellular Component: cytosol Molecular Function:aldo-keto reductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; protein binding; retinal dehydrogenase activity Biological Process: aldehyde metabolic process; digestion; farnesol catabolic process; retinoid metabolic process; steroid metabolic process |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60218 |
| NCBI GenInfo Identifier: | 322510010 |
| NCBI Gene ID: | 57016 |
| NCBI Accession: | O60218.2 |
| UniProt Secondary Accession: | O60218,O75890, Q6FHF3, Q8IWZ1, A4D1P1, |
| UniProt Related Accession: | O60218 |
| Molecular Weight: | 36,020 Da |
| NCBI Full Name: | Aldo-keto reductase family 1 member B10 |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member B10 |
| NCBI Official Symbol: | AKR1B10 |
| NCBI Official Synonym Symbols: | HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12 |
| NCBI Protein Information: | aldo-keto reductase family 1 member B10 |
| UniProt Protein Name: | Aldo-keto reductase family 1 member B10 |
| UniProt Synonym Protein Names: | ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase |
| Protein Family: | Aldo-keto reductase family |
| UniProt Gene Name: | AKR1B10 |
| UniProt Entry Name: | AK1BA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AKR1B10 antibody (CAB7823) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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