Anti-AKR1A1 Antibody (CAB13577)
- SKU:
- CAB13577
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-AKR1A1 Antibody |
| Antibody SKU: | CAB13577 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AKR1A1 (NP_006057.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, HT-29, Mouse kidney, Mouse liver, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AKR1A1 (NP_006057.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAS CVLL HTGQ KMPL IGLG TWKS EPGQ VKAA VKYA LSVG YRHI DCAA IYGN EPEI GEAL KEDV GPGK AVPR EELF VTSK LWNT KHHP EDVE PALR KTLA DLQL EYLD LYLM HWPY AFER GDNP FPKN ADGT ICYD STHY KETW KALE ALVA KGLV QALG LSNF NSRQ IDDI LSVA SVRP AVLQ VECH PYLA QNEL IAHC QARG LEVT AYSP LGSS DRAW RDPD EPVL LEEP VVLA LAEK YGRS PAQI LLRW QVQR KVIC IPKS ITPS RILQ NIKV FDFT FSPE EMKQ LNAL NKNW RYIV PMLT VDGK RVPR DAGH PLYP FNDP Y |
| Gene ID: | 10327 |
| Uniprot: | P14550 |
| Cellular Location: | |
| Calculated MW: | 36kDa |
| Observed MW: | 37kDa |
| Synonyms: | AKR1A1, ALDR1, ALR, ARM, DD3, HEL-S-6 |
| Background: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. |
| UniProt Protein Function: | AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family. |
| UniProt Protein Details: | Protein type:EC 1.1.1.2; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid Chromosomal Location of Human Ortholog: 1p33-p32 Cellular Component: cytosol; extracellular space Molecular Function:aldo-keto reductase activity; electron carrier activity; L-glucuronate reductase activity; protein binding Biological Process: aldehyde metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P14550 |
| NCBI GenInfo Identifier: | 113600 |
| NCBI Gene ID: | 10327 |
| NCBI Accession: | P14550.3 |
| UniProt Secondary Accession: | P14550,Q6IAZ4, A8KAL8, D3DQ04, |
| UniProt Related Accession: | P14550 |
| Molecular Weight: | 36,573 Da |
| NCBI Full Name: | Alcohol dehydrogenase |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member A1 |
| NCBI Official Symbol: | AKR1A1 |
| NCBI Official Synonym Symbols: | ALR; ARM; DD3; ALDR1; HEL-S-6 |
| NCBI Protein Information: | alcohol dehydrogenase [NADP(+)] |
| UniProt Protein Name: | Alcohol dehydrogenase [NADP(+)] |
| UniProt Synonym Protein Names: | Aldehyde reductase; Aldo-keto reductase family 1 member A1 |
| Protein Family: | Alcohol dehydrogenase |
| UniProt Gene Name: | AKR1A1 |
| UniProt Entry Name: | AK1A1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AKR1A1 antibody (CAB13577) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat kidney using AKR1A1 antibody (CAB13577) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using AKR1A1 antibody (CAB13577) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using AKR1A1 antibody (CAB13577). |
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