Anti-AKR1A1 Antibody (CAB1068)

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SKU:
CAB1068
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-AKR1A1 Antibody
Antibody SKU:CAB1068
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AKR1A1 (NP_006057.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, HT-29, 293T, LO2, Mouse kidney, Mouse liver, Rat kidney, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AKR1A1 (NP_006057.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAS CVLL HTGQ KMPL IGLG TWKS EPGQ VKAA VKYA LSVG YRHI DCAA IYGN EPEI GEAL KEDV GPGK AVPR EELF VTSK LWNT KHHP EDVE PALR KTLA DLQL EYLD LYLM HWPY AFER GDNP FPKN ADGT ICYD STHY KETW KALE ALVA KGLV QALG LSNF NSRQ IDDI LSVA SVRP AVLQ VECH PYLA QNEL IAHC QARG LEVT AYSP LGSS DRAW RDPD EPVL LEEP VVLA LAEK YGRS PAQI LLRW QVQR KVIC IPKS ITPS RILQ NIKV FDFT FSPE EMKQ LNAL NKNW RYIV PMLT VDGK RVPR DAGH PLYP FNDP Y
Gene ID:10327
Uniprot:P14550
Cellular Location:
Calculated MW:36kDa
Observed MW:37kDa
Synonyms:AKR1A1, ALDR1, ALR, ARM, DD3, HEL-S-6
Background:This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
UniProt Protein Function:AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family.
UniProt Protein Details:

Protein type:EC 1.1.1.2; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: cytosol; extracellular space

Molecular Function:aldo-keto reductase activity; electron carrier activity; L-glucuronate reductase activity; protein binding

Biological Process: aldehyde metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate

NCBI Summary:This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
UniProt Code:P14550
NCBI GenInfo Identifier:113600
NCBI Gene ID:10327
NCBI Accession:P14550.3
UniProt Secondary Accession:P14550,Q6IAZ4, A8KAL8, D3DQ04,
UniProt Related Accession:P14550
Molecular Weight:36,573 Da
NCBI Full Name:Alcohol dehydrogenase
NCBI Synonym Full Names:aldo-keto reductase family 1 member A1
NCBI Official Symbol:AKR1A1  
NCBI Official Synonym Symbols:ALR; ARM; DD3; ALDR1; HEL-S-6  
NCBI Protein Information:alcohol dehydrogenase [NADP(+)]
UniProt Protein Name:Alcohol dehydrogenase [NADP(+)]
UniProt Synonym Protein Names:Aldehyde reductase; Aldo-keto reductase family 1 member A1
Protein Family:Alcohol dehydrogenase
UniProt Gene Name:AKR1A1  
UniProt Entry Name:AK1A1_HUMAN
Anti-AKR1A1 Antibody (CAB1068)Western blot analysis of extracts of various cell lines, using AKR1A1 antibody (CAB1068) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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